 Along with PGF2α acting through its FP receptor, TXA2 acting through TP contracts uterine smooth muscle preparations from rodents and humans.Since the human uterous loses its sensitivity to PGP2α but not to TXA2 during the early stages of labor in vaginal childbirth, TP agonists, it is suggested, might be useful for treating preterm labor failures.Activation of TP receptors stimulates vascular endothelial cell pro-inflammatory responses such as increased expression of cell surface adhesion proteins (i.e.