 In 2000, Dr. James Shapiro and colleagues published a report describing seven consecutive people who achieved euglycemia following islet transplantation using a steroid-free protocol and large numbers of donor islets, since referred to as the Edmonton protocol.This protocol has been adapted by islet transplant centers around the world and has greatly increased islet transplant success.The goal of islet transplantation is to infuse enough islets to control the blood glucose level removing the need for insulin injections.