 LTC4 also stimulated lung expression of the pro-inflammatory intracellular adhesion molecules, ICAM-1 and VCAM-1 by a TP receptor-dependent mechanism.These findings suggest that TP contributes to asthma in animal models at least in part by mediating the actions of LTC4.Further studies are required to determine if TP receptor antagonists might be useful for treating asthma and other airway constriction syndromes such as chronic obstructive lung diseases in humans.