 The route passes through the center of Hamden, prior to intersecting the western end of the Route 40 freeway, which provides access to I-91; a flyover ramp exists from southbound Route 10 to eastbound Route 40.Past Route 40, Route 10 immediately intersects the western terminus of Route 22, which heads east towards North Haven, prior to passing near the campuses of Quinnipiac University and Sleeping Giant State Park in the Mount Carmel neighborhood.At this point, Route 10 reduces to two lanes and begins to parallel the Farmington Canal to the east, before it leaves Hamden and becomes the Main Street of the town of Cheshire.