 In 2004, Oquendo got another shot at a belt against WBA heavyweight title holder John Ruiz, losing by TKO in round 11.Oquendo then took 2 years off for surgery to repair a torn lab-rum, returning early 2006.Quick wins against Brazilian champ Daniel Bispo and then Javier Mora set up a fight against Evander Holyfield, which Holyfield won by unanimous decision on November 10, 2006 at the Alamodome in San Antonio, Texas.