 On 11 February 2009, he scored his first senior international goal in a friendly match against Cyprus, netting the second goal in his team's 3–2 defeat.On 1 April 2009, Jendrišek scored his first competitive international goal at senior level, netting the decisive second goal in Slovakia's 2–1 away victory against the Czech Republic in the 2010 FIFA World Cup qualifiers.In the 2010 World Cup finals in South Africa, Jendrišek featured in all three of Slovakia's group stage matches.