 Shortly after leaving the village, the route heads to the northeast along the base of a series of mountains delimiting the Canandaigua Lake valley, entering Yates County and the town of Italy before following the valley surrounding the West River at a fork in the primary valley near the southern end of Canandaigua Lake.NY 245 follows the eastern edge of the valley to the town of Middlesex, where it intersects NY 364 in the hamlet of the same name's center.NY 245 and NY 364 run concurrent for a block before NY 364 splits from NY 245 to ascend the eastern edge of the valley and continue towards Potter.