 Argegno is of Roman origin, and is named after the Roman consul Publio Cesio Archigene.With the fall of Rome and the subsequent geopolitical instability in Italy a series of fortifications were constructed in the medieval period, including the arched bridge which still stands.The largest structure in the village is the Sanctuary of Sant'Anna, which was constructed in the seventeenth century, and contains stucco work from later time.