 In his major league debut on August 30, 2006 against the Los Angeles Angels of Anaheim, he struck out Howie Kendrick, the only batter he faced in innings pitched.Before being promoted to the majors, Huber was 3–1 with a 2.61 ERA and 12 saves in 13 chances with the Triple-A Tacoma Rainiers.He appeared in 16 games with the Mariners in 2006 and another 9 in 2007, with a 2-1 record and 2.57 ERA.