 He has made many contributions to gene finding algorithms, notably the GLIMMER program for bacterial gene finding as well as several related programs for finding genes in animals, plants, and other organisms.He has also been a leader in genome assembly research and is one of the initiators of the open source AMOS project.He was a participant in the human genome project as well as many other genome projects, including the malaria genome ("Plasmodium falciparum") and the genome of the model plant "Arabidopsis thaliana".