 In the "Derby della Capitale" against Rome rivals Lazio, Borriello scored the opener in the second half as Roma win 2–0 and scored again from the penalty, on 19 January 2011, in the round of 16 of the Coppa Italia, which Roma won 2–1 once more.Borriello finished with 17 goals (in all competitions) for Roma in the 2010–11 season, making him a second top scorer behind Francesco Totti.With the arrival of new coach Luis Enrique, Borriello came to be considered surplus to the team's needs.