 On January 19, 2011, Heller voted to repeal the Affordable Care Act (Obamacare).In May 2013, Heller introduced a bill to suspend $440 million in IRS funding to enforce Obamacare.In June 2013, Heller called Obamacare a “colossal monstrosity,” but in April 2014, The Hill named him as one of several “anxious Senate Republicans” who were worried that Republican leaders were “focusing too much this election year on Obamacare.”

In June 2017, Heller held a joint press conference with Nevada Governor Brian Sandoval, where Heller fervently opposed the American Health Care Act, the Republican Party's repeal and replacement bill for the Affordable Care Act (ACA).