 A segment of the highway in Saline County overlaps Interstate 135 (I-135) and US-81, and a section in Topeka runs concurrent with I-70.It also intersects several other major highways, including US-283 in Ransom, US-183 in La Crosse, US-281 in Hoisington, US-77 in Herington, I-470 and US-75 in Topeka, and US-24 northeast of Topeka.K-4 was first designated by KDOT in 1927, and at that time ran from K-1 (now U.S. Route 183) in La Crosse eastward to the Missouri state line by Atchison.