 Homeometric autoregulation, in the context of the circulatory system, is the heart's ability to increase contractility and restore stroke volume when afterload increases.Homeometric autoregulation occurs independently of cardiomyocyte fiber length, via the Bowditch and/or Anrep effects.This is in contrast to heterometric regulation, governed by the Frank-Starling law, which results from a more favorable positioning of actin and myosin filaments in cardiomyocytes as a result of changing fiber lengths.