 His leading disciple was Rabbi Yehuda Leib Eiger (1816-1888), grandson of Rabbi Akiva Eiger.His students included Rabbi Zadok HaKohen of Lublin (1823–1900), his son, Rabbi Yaakov Leiner (1828–1878) and his grandson Rabbi Gershon Henoch Leiner of Radzyn.Mordechai Yosef Leiner is buried in an ohel in the Jewish cemetery in Izbica.