 Thus, P became the first clearly defined metazoan example of this long-suspected phenomenon.His research group also worked on the nature of metazoan gene regulation (Zachar and Bingham, 1985) and the elucidation of the first case of autoregulation of gene expression at the level of pre-mRNA splicing (Chou, et al., 1987; Zachar, et al., 1987; Bingham, et al., 1988; Spikes et al., 1994) and of critical features of the nuclear organization of pre-mRNA processing and transport (Li and Bingham, 1991; Zachar, et al., 1994).This latter work first clearly established the now-widely accepted model of channeled diffusion for the movement of most pre-mRNAs through the nuclear compartment (reviewed in Kramer, et al., 1994).