 Vázquez had a wife, Deisi Valencia, who served as the mayor of San Juan Evangelista.Vázquez had two daughters, including Fabiola Vázquez Saút, the former mayor of Acayucan, and Regina Vázquez Saút, a former federal congressperson.Vázquez also had an older brother, Ponciano Vázquez Lagunes; in June 2006, several kidnappers kidnapped Ponciano, demanded the equivalent of two million U.S. dollars in return for Ponciano's release, and killed Ponciano.