 The eosinophilic reaction is common in feline inflammatory disease and the eosinophilic granuloma can be a hereditary reaction pattern in some lines of domestic cats.In humans, eosinophilic granulomas are considered a benign histiocytosis that occurs mainly in adolescents and young adults.Clinically, unifocal lytic lesions are found in bones such as the skull, ribs and femur.