 They are crucial for the metabolic and trophic support of neurons; additionally, astrocytes provide ion buffering and neurotransmitter clearance.Growing axons are guided by cues created by astrocytes; thus, astrocytes can regulate neurite pathfinding and subsequently, patterning in the developing brain.The glial scar that forms post-injury in the central nervous system is formed by astrocytes and fibroblasts; it is the most significant obstacle for regeneration.