 He set a club record with four takeaways in one game (three interceptions, one fumble recovery) versus the Miami Dolphins in 1980 to help the Bills snap a 20-game losing streak against Miami.Nixon suffered a career-ending knee injury in 1984.Nixon appeared on the 1978 College Football All-America Team with Bob Hope 

During the Buffalo Bills football season, Nixon worked as a sports analyst on WKBW-TV's AM Buffalo from 2002 to 2008.