 Di Ruberto was born in Pietra Montecorvino, and was ordained to the priesthood on 29 September 1957.He graduated from the Pontifical Lateran University and the University of Naples, and then entered the Roman Curia in the Congregation for the Causes of Saints in 1969.In 1984, Di Ruberto was placed in charge of verifying miracles attributed to candidates for canonization, and in 1993 was named the Congregation's Undersecretary.