 A novel biodegradable, tough elastomer has been developed from poly(glycerol sebacate) (PGS) for use in creation of a nerve guidance conduit.PGS was originally developed for soft tissue engineering purposes to specifically mimic ECM mechanical properties.It is considered an elastomer because it is able to recover from deformation in mechanically dynamic environments and to effectively distribute stress evenly throughout regenerating tissues in the form of microstresses.