 Smith eventually came to the conclusion that it was bacteriologically impossible to inoculate against snake-bite, but while carrying out his investigations he collected a large amount of information about the relative virulence of the venom of Australian snakes.His most important research was in connection with anthrax.Louis Pasteur had discovered a vaccine, which, however, would not keep, and Smith after long experimenting found an effective vaccine which would keep for an indefinite period.