 By virtue of an enzyme's capacity to form stereospecific and non-covalent complexes with specific substrate, the substrate is correctly presented in the precise orientation that specifies the catalytic effect of the enzyme.Monod reminds us that this reaction comes at the expense of chemical potential energy.In chapter four ("Microscopic Cybernetics") the author starts out by repeating the characteristic of extreme specificity of enzymes and the extreme efficiency of the chemical machinery in living organisms.