 Matsys departed from Leuven in 1491 when he became a master in the guild of painters at Antwerp.His most well known satirical works include "The Ugly Duchess" (1515), "A Portrait of an Elderly Man" (1513), and "The Money Changer and His Wife" (1514), all of which provide commentary on human feeling and society in general.He also painted religious altarpieces and triptych panels, the most famous of which was built for the Church of Saint Peter in Leuven.