 His "Virgin and Christ", "Ecce Homo" and "Mater Dolorosa" (London and Antwerp) are known for their serene and dignified mastery, gaining in delicacy and nuance in the works of his maturity.It is believed that he had known the work of Leonardo da Vinci in the form of prints made and circulated among northern artists (his "Madonna and Child with the Lamb", inspired by "The Virgin and Child with St. Anne", reflects da Vinci's influences).This is largely regarded as proof that Matsys was greatly influenced by Italian Renaissance artists and that he most likely travelled to Italy for at least a brief period.