 Problems with its use include opiate dependency and analgesia which can mask symptoms of diseases that need treatment.However, Paregoric was characterized as "a needlessly complex pharmacopeial mixture... of a former day" by a 1966 study.In the 21st century its two main uses have been largely supplanted by minimally psychoactive cough-suppressant drugs (such as dextromethorphan) and non-psychoactive antidiarrheal drugs (such as loperamide).