 Following Indian Removal of the Creek in the 1830s to Indian Territory west of the Mississippi River by the US government, this area was settled by European Americans.The town of Wedowee was designated as the county seat of Randolph County in 1835.The county was developed for the cultivation of cotton as a commodity crop, with labor primarily done by enslaved African Americans, many of whom had been sold to the Deep South from the Upper South in the domestic slave trade.