 In the United States, the Harrison Narcotics Act of 1914 regulated "opium or coca leaves, or any compound, manufacture, salt, derivative or preparation thereof", but not some medical products containing relatively low concentrations of these substances.Paregoric was classified as an "Exempt Narcotic", as were other medical products containing small amounts of opium or their derivatives.In 1929-30, Parke, Davis & Co., a major United States drug manufacturer based in Detroit, Michigan, sold "Opium, U.S.P.