 Genevieve in Missouri were the main towns, but there was little new settlement.France regained Louisiana from Spain in exchange for Tuscany by the terms of the Treaty of San Ildefonso in 1800.Napoleon had lost interest in re-establishing a French colonial empire in North America following the Haitian Revolution and together with the fact that France could not effectively defend Louisiana from Great Britain, he sold the territory to the United States in the Louisiana Purchase of 1803.