 When disagreement arose between the two men, forces were set in motion that resulted in the formation of the doctrine of the Trinity.In the Nicene Creed adopted at the First Council of Nicaea in 325, wherein the Roman Emperor Constantine the Great got involved, the issue was considered settled and the adoption of Alexander's view became the orthodox doctrine and all other views were considered heresy and officially suppressed.During the reign of the emperor Constantius II, however, the anti-Nicene party rose to prominence and exercised considerable control over the church for about a generation.