 Starting at the Florida line south of Quitman in Brooks County, US 221 heads north concurrent with SR 76.Just south of Quitman, both roads merge with an at-grade interchange with SR 333 until they reach downtown Quitman, passing over a railroad bridge over a former Atlantic Coast Line Railroad line.US 221/SR 76/SR 333 turn east at US 84/SR 38 in front of the Brooks County Probate Courthouse and all five routes stay concurrent until the intersection with Washington Street where SR 76/333 split off to the north.