 A defensive holding penalty on Patriots cornerback Deltha O'Neal on third down extended the drive, leading to a 16-yard touchdown catch by running back Frank Gore that gave the 49ers a 7–0 lead.On the Patriots' next drive, a fumbled snap by Cassel set up 3rd and 8 from the Patriots' own 34-yard line; Cassel then threw a deep pass to Moss, which was caught at the 49ers' 21-yard line and run in for a 66-yard touchdown that tied the game at 7–7.A 38-yard Isaac Bruce reception from O'Sullivan on the 49ers' ensuing possession backed the Patriots' defense up to their own 22-yard line, and two plays later, O'Sullivan and Bruce again connected on a pass, this one a touchdown from 6 yards out to give the 49ers a 14–7 lead.