 Ranzano would go on to join the Dominican Order at the age of sixteen and by the time he was twenty-eight, he had become Provincial of the Dominicans in Sicily.Around the year 1464, Ranzano would be appointed papal nuncio in the kingdom of Sicily and he would be entrusted with the organization of the crusade against the Turks in conjunction with preaching and collecting funds for the aforementioned crusade.While in Palermo, Ranzano taught at the Dominican College.