 Another example is in the synthesis of antimalarials as aminoalkylamino derivatives of 2,3-dihydrofuroquinolines

The Gould reaction is also used to convert 5-aminoindole to quinolines for the purpose of synthesizing pyrazolo[4,3-"c"]pyrrolo[3,2-"f"]quinolin-3-one derivatives as modified pyrazoloquinolinone analogs.These compounds have the potential to act as antagonists at central benzodiazepine receptors (BZRs) in "Xenopus laevis" oocytes.The Gould‐Jacobs reaction has also been used both conventionally with condensation steps and acyclic intermediated and with single step microwave irradiation to synthesize ethyl 4‐oxo‐8,10‐substituted‐4,8‐dihydropyrimido[1,2‐c]pyrrolo[3,2‐e]pyrimidine‐3‐carboxylates.