 Around the year 1464, Ranzano would be appointed papal nuncio in the kingdom of Sicily and he would be entrusted with the organization of the crusade against the Turks in conjunction with preaching and collecting funds for the aforementioned crusade.While in Palermo, Ranzano taught at the Dominican College.Ranzano’s personality and education influenced his work, creating a particular mixture of secular and religious learning that arguably can be perceived as the hallmark of Sicilian humanism.