 It is especially active against Shigella species., Salmonella sp., Escherichia coli, Branhamella catarrhalis, Haemophilus influenzae, Neisseria gonorrhoeae, Yersinia enterocolitica, Serratia marcescens, Staphylococcus aureus, Pseudomonas aeruginosa.After oral administration fleroxacin is rapidly and well absorbed from the gastrointestinal tract and shows a good bioavailability.The antibiotic is widely distributed throughout the body and in the different biological tissues.