 The antibiotic should not be administered to patients with epilepsy or a personal history of previous convulsive attacks as may promote the onset of these disorders.Fleroxacin is contraindicated in patients with a history of hypersensitivity to the substance or any other member of the quinolone class, or any component of the medicine.Fleroxacin, like other fluoroquinolones, can cause degenerative changes in weightbearing joints of young animals.