 Mirza joined Pakistan Peoples Party (PPP) in 1997 and was elected to the National Assembly of Pakistan as a candidate of PPP from Constituency NA-173 (Badin-II) in 1997 Pakistani general election.She was re-elected to the National Assembly as a candidate of PPP from Constituency NA-225 (Badin-II) in 2002 Pakistani general election.She received 71,537 votes and defeated Khan Mohammad Halipota, a candidate of Pakistan Muslim League (Q) (PML-Q).