 Ranzano would study Latin at the school of humanist Antonio Cassarino, who at the time was a teacher of young children (magister scholae parvulorum) in Palermo.Like other scholars of his era, he would study at various institutions which were headed by various masters such as Pietro Aretino in Florence, Tommaso Pontano in Perguia, and Vitaliano Borromeo and Pietro Candido Decembro in Milan and Pavia.Ranzano would go on to join the Dominican Order at the age of sixteen and by the time he was twenty-eight, he had become Provincial of the Dominicans in Sicily.