 Many of the works of Mark Twain deal with or take place near the Mississippi River.One of his first major works, "Life on the Mississippi", is in part a history of the river, in part a memoir of Twain's experiences on the river, and a collection of tales that either take place on or are associated with the river.Twain's most famous work, "Adventures of Huckleberry Finn", is largely a journey down the river.