 Hotchkiss continued working in molecular genetics until his retirement in 1982, including significant collaborations with Julius Marmur, Maurice Fox, Alexander Tomasz, Joan Kent, Sanford Lacks, Elena Ottolenghi, and his wife Magda Gabor-Hotchkiss.In the mid-1960s, Hotchkiss became interested in the potential dangers of genetic engineering (a term he helped to popularize).Through the early 1970s he articulated many of the concerns that led to the 1975 Asilomar Conference on Recombinant DNA.