 The conflicting findings associated with mPFC stimulation, when compared to the relatively specific findings in the infralimbic cortex, suggest that the prelimbic cortex and infralimbic cortex may mediate opposing effects.mPFC projections to the raphe nuclei are largely GABAergic and inhibit the firing of serotonergic neurons.Specific activation of these regions reduce immobility in the forced swim test but do not affect open field or forced swim behavior.