 Overall, the genetic makeup of Japanese Americans show very mixed origins of genes, all due to the result of migrations of the Japanese ancestors in the past.Studies have looked into the risk factors that are more prone to Japanese Americans, specifically in hundreds of family generations of Nisei ("The generation of people born in North America, Latin America, Hawaii, or any country outside Japan either to at least one Issei or one non-immigrant Japanese parent)" second-generation pro-bands ("A person serving as the starting point for the genetic study of a family, used in medicine and psychiatry).