 The mutations correlated with decreased CETP levels (-35%) and increased HDL cholesterol levels (+10% for D442G).The relative risk of CHD was 1.43 in men with mutations (P<0.05), and after research found for CHD risk factors, the relative risk went up to 1.55 (P=0.02); after further adjustments for HDL levels, the relative risk went up again to 1.68 (P=0.008).Genetic CETP deficiency is an independent risk factor for coronary heart disease, which is due mainly to increased CHD risks in Japanese American men with the D442G mutation and lipoprotein cholesterol levels between 41 and 60 mg/dl.