 The salience network is a cingulate-frontal operculum network that includes core nodes in the anterior cingulate and anterior insula.A salience network is a large-scale brain network involved in detecting and orienting the most pertinent of the external stimuli and internal events being presented.Individuals who have a tendency to experience negative emotional states (scoring high on measures of neuroticism) show an increase in the right anterior insula during decision-making, even if the decision has already been made.