 Regions involved in reward are common targets of manipulation in animal models of depression, including the nucleus accumbens (NAc), ventral tegmental area (VTA), ventral pallidum (VP), lateral habenula (LHb) and medial prefrontal cortex (mPFC).Tentative fMRI studies in humans demonstrate elevated LHb activity in depression.The lateral habenula projects to the RMTg to drive inhibition of dopamine neurons in the VTA during omission of reward.