 Numerous studies suggest that the subgenual cingulate plays an important role in the dysfunction that characterizes major depression.The increased activation in the default mode network during rumination and the atypical connectivity between core default mode regions and the subgenual cingulate may underlie the tendency for depressed individual to get “stuck” in the negative, self-focused thoughts that often characterize depression.However, further research is needed to gain a precise understanding of how these network interactions map to specific symptoms of depression.