 He also studied at the University of Virginia, the Moscow Arts Theatre, and the Royal National Theatre in London.Basing himself in Los Angeles, Mwine's first professional job was the role of Paul in the 1992 U.S. National Tour of "Six Degrees of Separation", for which he received an NAACP Image Award nomination for Best Actor.Mwine has also expressed his views on sticky subjects including LGBTQ , HIV/AIDS and the art in him that moves him to tell stories

Mwine has appeared in movies including "Blood Diamond", where he made his film debut.