 On January 23, 2011, it was announced that he would play in the 2011 Pro Bowl as a replacement for Packers linebacker Clay Matthews III who was appearing in Super Bowl XLV.On January 30, 2011, Orakpo recorded seven combined tackles as part of the NFC during their 55–41 victory against the AFC.Head coach Mike Shanahan named Orakpo and Ryan Kerrigan the starting outside linebackers to start the regular season, along with inside linebackers London Fletcher and Rocky McIntosh.