 She had a sister Margery de Welles, who married firstly, John de Huntingfield, 1st Baron Huntingfield and secondly, Stephen Scrope, 2nd Baron Scrope of Masham.Her paternal grandparents were Sir Adam de Welles, 3rd Baron Welles and Margaret Bardolf, and her maternal grandparents were William de Ros, 2nd Baron de Ros and Margery Badlesmere, the eldest daughter of Bartholomew de Badlesmere, 1st Baron Badlesmere and Margaret de Clare.Prior to 17 June 1386, Anne Welles married James Butler, 3rd Earl of Ormond (died 6 September 1405), son of James Butler, 2nd Earl of Ormond and Elizabeth Darcy.