 During his first year at Rice, McGuffie had the third highest rushing yardage total of any back in Conference USA, with 883 yards and six touchdowns.He also had receiving totals of 384 yards and three touchdowns, making him one of only three players in the NCAA Football Bowl Subdivision to gain both 880 yards rushing and 380 yards receiving in 2010.McGuffie missed several games during the 2011 season because of injuries, including the last five games of the season.