 In 2006, Chigwedere delivered the Lowell Lecture at the Boston Museum of Science, and he was the keynote speaker at the 2006 International Conference on
AIDS Orphans and Vulnerable Children where he was honored by the Boston City Council for his efforts in fighting the AIDS epidemic in Africa.In 2011, Chigwedere was honoured as one of Ten Outstanding Young Zimbabweans by Junior Chamber International, for his contributions to medical science and research.In 2015, Chigwedere was awarded the Harvard Chan Alumni's Emerging Public Health Leader Award for his work "at the center of the AIDS Response" in Africa.