 Acne affects most individuals with PAPA syndrome but to a variable degree.It is usually of a severe nodulocystic type which if untreated results in scarring.PAPA syndrome is inherited in an autosomal dominant fashion, which means that if one parent is affected, there is a 100% chance that a child will inherit the disease from a homozygous affected parent and a 50% chance that a
child will inherit the disease from an affected heterozygous parent.