 Mokane is located on the north side of the Missouri River valley along Missouri Route 94 between Tebbetts to the southwest and Steedman to the northeast.Fulton lies about twelve miles to the north along Missouri Route N. The Katy Trail, a rails-to-trails hiking/biking path, runs through the town, which stands at mile 125.According to the United States Census Bureau, the city has a total area of , all land.