 In the adult nervous system, CRMP expression is significantly downregulated and limited in areas associated with brain plasticity, neurogenesis, or regeneration.CRMP1 mRNA is mainly expressed in Purkinje cells of the cerebellum.Among the five members of the CRMP family, CRMP-2 is the most highly expressed in the adult brain, especially in post-mitotic neurons of the olfactory system, cerebellum, and hippocampus.