 Gel filtration analysis has shown that CRMP-5 and CRMP-1 form weaker homo-tetramers compared with CRMP-2, and that divalent cations, Ca2+ and Mg2+, destabilize oligomers of CRMP-5 and CRMP-1, but promote CRMP-2 oligomerization.The C-terminus consists of 80 amino acids and is the site of phosphorylation for various kinases.The expression of CRMPs is regulated throughout development of the nervous system.