 In DRG neurons, CRMP-2 is phosphorylated by Rho kinase in LPA signaling but not in Sema3A signaling, revealing the presence of both Rho kinase-dependent and Rho kinase-independent pathways for the growth cone collapse.In RhoA pathway, CRMP-1 interacts with Rho-kinase and modulates RhoA signaling.CRMP-2 can be regulated post-translationally by O-GluNAc (β-N-acetylglucosamine linked to hydroxyls of serine or threonine) as the modification blocks CRMP-2 from being phosphorylated.