 CRMP-3 is not the only CRMP involved in neuronal degeneration brought upon by trauma and cerebral ischemia, as all CRMPs are in fact targeted for cleavage to help promote degeneration.The expression of CRMPs is altered in neurodegenerative diseases and these proteins likely play an essential role in the pathogenesis of disorders in the nervous system, including Alzheimer's disease, Parkinson's disease, schizophrenia, and many others.One pharmaceutical that is relatively effective in targeting CRMP-2 to reduce the results of a neurodegenerative disease is lacosamide.