 However this process will modify all cells in contact with the constructs and usually require significantly more construct than "in vitro" preparation, as FSL constructs will preferentially associate with free lipids.The "in vivo" creation of kodecytes is untargeted and FSL constructs will insert into all cells non-specifically, but may show a preference for some cell types.Diagnostic serological analyses including flow cytometry and scanning electron microscopy usually can't see a difference between "kodecytes" and unmodified cells.