 In the presence of CRMP-2, the signal can induce alterations of Rac-dependent pathway, which modulates the actin filament assembly in the growth cone.Moreover, CRMP-2 is involved in another growth cone collapse signal induced by extracellular lysophosphatidic acid (LPA).A signal through seven-transmembrane receptor activates an intracellular pathway, RhoA and the downstream of RhoA, Rho-kinase subsequently phosphorylates CRMP-2 on Threonine-555 (Thr555).