 Abi-Dargham has used molecular imaging techniques, such as single photon emission computed tomography (SPECT) and positron emission tomography (PET), to study the pathophysiology of schizophrenia, schizophrenia-related spectrum disorders, and addiction.With her collaborators, Abi-Dargham has done PET and fMRI studies on dopamine receptor density and network connectivity in both healthy individuals and patients with schizophrenia.Her work has resulted in seminal publications describing the complex alterations of dopamine transmission in schizophrenia and their relationship to clinical symptoms, cognition and response to treatment, as well as their interrelatedness to glutamate dysfunction in schizophrenia.