 Cleaved CRMP products play a considerable role in the degeneration of axons as a result of trauma inflicted on the central nervous system (CNS).As a result of trauma induced on the CNS, glutamate activates NMDA receptors leading to an influx of calcium that activates the calcium-dependent protease calpain.It has been shown that activated calpain proteolytically cleaves CRMP-3, creating a cleavage product of CRMP that interacts with vital cytosolic and nuclear molecules to bring about neurodegeneration.