 Members of the CRMP family were discovered independently in different species by several groups working in parallel.Among the five members of the family, CRMP-2 was first identified in 1995.Group of researchers led by Goshima found out that CRMP-2 played a role in the transduction of the extracellular Semaphorin 3A (Sema3A), an inhibitory protein for axonal guidance in chick dorsal root ganglion (DRG).