 In following researches, CRMPs were studied as target antigens for autoantibodies in various autoimmune neurodegenerative disorders.CRMP1-5 are between 564-572 amino acids and these proteins are found to be approximately 95% conserved between mouse and human.The protein sequence of CRMP1-4 is approximately 75% homologous with each other, while CRMP5 is only 50-51% homologous with each of the other CRMPs.