 She moved to the UK in 1982 and worked as a Junior House Officer at the Glasgow Royal Infirmary, and a Senior House Officer and Registrar at the Royal Alexandra Hospital, Paisley.In 1986, she gained Membership of the Royal College of Physicians UK.In 1986, Dominiczak was appointed Medical Research Council (MRC) Clinician Scientist and Senior Registrar at the Western Infirmary, Glasgow, and between 1990 and 1991 was Research Fellow and Associate Professor at the University of Michigan on a British Heart Foundation Fellowship.