 Tsan Yuk Hospital was originally located at the cross-section of Western Street and Third Street in Hong Kong's Sai Ying Pun district.The land on which the hospital was built was donated by the government and the $94,000 construction fee was donated by Mr. H. M. H Nemazee, Sai Ying Pun Kai Fong Committee () of the Fishmongers' Guild () and Fruit and Vegetable Sellers' Guild ().The thirty beds were donated by Tung Wah Hospital, another government hospital located in neighbouring Sheung Wan.