 On September 10, 2017, in his 49ers debut, Goodwin had three receptions for 21 yards in the season opening 23–3 loss to the Carolina Panthers.On November 12, 2017, against the New York Giants, he caught his first touchdown of the season on an 83-yard reception.After beating one defender, Goodwin blew a kiss to the sky and once in the end zone, then took a knee in prayer before falling to both knees with his head in hands, as his teammates gathered around him.