 In the 16th century, a number of Wysłouchs held important public offices, including a Royal Castellany, and at the end of the 18th century Zenon Kazimierz Wysłouch was one of the members of the Great Sejm, the Polish Parliament which created the Constitution of May 3, 1791.Bolesław and Antoni Izydor Wysłouch were prominent liberal politicians and members of the Parliament in the inter-war period, the former being a co-founder of the PPS "Piast" party.Members of the Wysłouch family were involved in the independence movement during the Partitions of Poland.