 They have a short cytoplasmic N-terminal, one transmembrane domain, and a large C-terminal Golgi luminal domain.They are distinct from cytosolic sulfotransferases in both structure and function.While cytosolic sulfotransferases play a metabolic role by modifying small molecule substrates such as steroids, flavonoids, neurotransmitters, and phenols, carbohydrate sulfotransferases have a fundamental role in extracellular signalling and adhesion by generating unique ligands through the modification of carbohydrate scaffolds.