 She was the daughter of Innico I d'Avalos of the Spanish d'Avalos family, count of Monteodorisio, and Antonella d'Aquino, heiress to the marquisate of Pescara.Her father had come to Italy with Alfonso V of Aragon in 1442.She was given in marriage to Federico del Balzo, Prince of Altamura and Duke of Venosa, son of Pietro del Balzo and brother of the Queen of Naples, Isabella.