 On 7 August 2010, the newly elected President, Juan Manuel Santos Calderón appointed her to serve as the 5th Minister of Environment, Housing and Territorial Development.During her time in the Ministry she oversaw the restructuring of the Ministry separating the housing and territory portfolios from that of environment, thus creating two separate ministries in the cabinet.On 27 September 2011 Uribe was reappointed as the 1st Minister of Housing, City and Territory, serving until 17 May 2012 when she was replaced by Germán Vargas Lleras.