 He has prosecuted a number of significant cases including the shotgun murder at the "Marmion" public house in Edinburgh, the murder of Jolanta Bledaite, HM Advocate v Sheridan and Sheridan and the Murder of Surjit Singh Chhokar.In 2012 he twice won a murder conviction without a body in the murder of Suzanne Pilley and the retrial in the murder of Arlene Fraser.Further to this, Prentice won an appeal lodged by Fraser in 2013.