 However, a 2007 study found schizophrenia patients to have reduced olfactory sensitivity to TMHA, possibly indicating sensory habituation; the decreased ability to smell the substance due to the presence of the substance as a constant component of subjects' own sweat and body odor.Furthermore, the researchers noted a positive association between reduced ability to smell TMHA and greater severity of disorganised and negative symptoms.An allusion to TMHA and its purported link to the smell of the mentally ill is made in the 1996 David Foster Wallace novel, "Infinite Jest", and in the 1988 novel "The Silence of the Lambs" by Thomas Harris.