 Indeed, RNAi may be more effective against mRNA targets that are not translated.Argonaute proteins are localized to specific regions in the cytoplasm called P-bodies (also cytoplasmic bodies or GW bodies), which are regions with high rates of mRNA decay; miRNA activity is also clustered in P-bodies.Disruption of P-bodies decreases the efficiency of RNA interference, suggesting that they are a critical site in the RNAi process.