 Recent evidence suggests that resistance to RNAi could be broad-spectrum, meaning that resistance to one sequence could confer resistance to other dsRNA sequences.In one laboratory population of western corn rootworm, resistance occurred through lack of uptake of DvSnf7 dsRNA through the gut.When other dsRNA sequences were tested against DvSnf7, the other sequences were no longer effective which suggests that resistance management would be more difficult than simply switching out dsRNA sequences.