 The homotypic interaction with BCL10 is believed to be prevented by the linker region of CARD14, when in an inactive state.CARD14 overexpression leads to an activation of the transcription factor NF-κB and phosphorylation of BCL10.CARD14 has been shown to form a CBM signalosome, similar to the signalling of CARD11, with BCL10 and MALT1.