 Fish-eye disease is characterized by abnormalities like visual impairment, plaques of fatty material, and dense opacification.Both the familial type and Fish-eye disease are autosomal recessive disorders caused by mutations of the "LCAT" gene located on chromosome 16q22.1, which is the long (q) arm of chromosome 16 a position 22.1.Both diseases are very rare with ~70 reported cases of familial LCAT deficiency and ~30 cases of fish-eye disease.