 The chief opponent of that peace was Elisabeth Farnese, queen of Philip V of Spain, who hoped to create an Italian principality for her son.In 1718, the Emperor, France, Great Britain and the Netherlands signed the Quadruple Alliance against Spain.Article 5 of the alliance proposed to grant to Elisabeth Farnese's eldest son, Don Carlos, the future Charles III of Spain, the Grand Duchy of Tuscany with Porto Longone when the ruling House of Medici died out, as it was soon expected to.