 Even if he supported the doctrine of transubstantiation, he was a fierce opponent of the Catholic Church, and worked for the reunion of the Greek Church with the Coptic Church.In 1593 he participated in a synod in Constantinople which confirmed the establishment of the Patriarchate of Moscow.Without resigning as Patriarch of Alexandria, he served as locum tenens of the Ecumenical Patriarchate of Constantinople between December 1596 and February 1597, and from end March 1597 to March or April 1598, when he resigned to go on dealing only with his Egyptian see.