 Renfro was selected by the Houston Oilers in the fourth round (98th overall) of the 1978 NFL Draft.As a rookie, he started 10 out of 14 games, registering 26 receptions (third on the team) for 339 yards (third on the team) and 2 touchdowns.In 1979, he started 2 out of 15 games, collecting 16 receptions (tied for fifth on the team) for 323 yards (third on the team), a 20.2-yard average (led the team) and 2 touchdowns.