 The Indiana portion of I-65 begins in Jeffersonville after crossing the Ohio River and travels mainly north, passing just west of Columbus prior to reaching the Indianapolis metro area.Upon reaching Indianapolis, the route alignment of I-65 begins to run more to the northwest and subsequently passes Lafayette on that city's east and north sides.Northwest of there, in west-central Jasper County, the route again curves more northward as it approaches the Calumet Region.