 PA 572 was designated to run from PA 372 in Christiana to PA 41 in Atglen on an unpaved road, following Bridge Street and Valley Avenue.At this time, the current alignment east of Atglen was unnumbered and was paved between Parkesburg and Coatesville.By 1930, a separate section of PA 572 was designated onto the paved road between PA 42 (now PA 10) in Parkesburg and PA 82 in Coatesville.