 After President John F. Kennedy was assassinated, the Board of Education voted to change the name of the school from Iselin High School to John F. Kennedy Memorial High School at their meeting on November 26, 1963.The school opened in September 1964.The school was the 129th-ranked public high school in New Jersey out of 339 schools statewide in "New Jersey Monthly" magazine's September 2014 cover story on the state's "Top Public High Schools", using a new ranking methodology.