 PA 572 was designated from PA 372 in Christiana to PA 41 in Atglen.Another section of PA 572 was designated between PA 42 (now PA 10) in Parkesburg and PA 82 in Coatesville by 1930; these two sections were linked in 1937.In the 1940s, PA 372 was rerouted to its current eastern terminus, replacing PA 572.