 In 2007/2008, in the course of serving as a criminal defense lawyer for sex-offender Jeffrey Epstein, Lefkowitz negotiated a deal with prosecutor Alexander Acosta.Acosta would later come under attack for having made this agreement with Epstein's defense lawyers, and pressure connected with whether the deal was in the best interest of the prosecution led Acosta to resign his position as Secretary of Labor in 2019.In "Corber v. Xanodyne Pharmaceuticals Inc.", the Ninth Circuit, sitting "en banc", ruled in favor of Lefkowitz’s client, Teva Pharmaceuticals.