 For the past 30 years Chaldakov has been involved in interdisciplinary research in the fields of vascular biology, and has had relationship with suchadipobiology, and neurobiology and is one of the pioneers establishing the novel concept of the secretory function/phenotype of the vascular smooth muscle cells and further delineating their role in atherogenesis.Chaldakov developed a complex tripartite model of atherogenesis which involve smooth muscle cells, immune cells, and perivascular adipose tissue communicating through secreted factors (e.g.neurotrophins, adipokines, cytokines).