 She is known to have been a contralto soloist, violinist, and composer during the tenures of Giovanni Porta, Nicola Porpora, and Andrea Bernasconi as heads of the school.She is also known to have studied violin with Anna Maria della Pietà (also named ″Anna Maria dal violin″) and to have succeeded her as director of the school orchestra around 1740; at this time she performed at least six of the concertos written by Antonio Vivaldi for Anna Maria.One piece by Santa, a setting of the Vespers Psalm 113 in D, survives.