 PA 372 heads east from PA 74 in York County and crosses the Susquehanna River on the Norman Wood Bridge.The route continues through Lancaster County, intersecting PA 272 in Buck, U.S. Route 222 (US 222) and PA 472 in Quarryville, and PA 896 in Georgetown.PA 372 crosses into Chester County and intersects PA 41 in Atglen and PA 10 in Parkesburg before continuing to Coatesville.