 Innexons are made from eight subunits, instead of the six subunits of connexons.Structurally, innexins and connexins are very similar, consisting of 4 transmembrane domains, 2 extracellular and 1 intracellular loop, along with intracellular N- and C-terminal tails.Despite this shared topology, the protein families do not share enough sequence similarity to confidently infer common ancestry.