 DeRenzo has worked with Nile's Project to help stop MRSA through public awareness concerts featuring his Beatles tribute band "Joe DeRenzo & Friends, a jazzy tribute to The Beatles".DeRenzo was born and raised in Orange County, California, and resided in the city of Anaheim and in what is now known as Anaheim Hills for the early part of his life through 1970.It was during these years that his interest in music began by way of his dad's record collection which included the LPs of Frank Sinatra, Ray Charles, Louie Bellson and Boots Randolph.