 As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and .Glutathione synthase catalyzes the chemical reaction

The 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and glycine, whereas its 3 products are ADP, phosphate, and glutathione.This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).