 On 15 August 2011, Portuguese club FC Porto agreed with Standard Liége to buy the sporting rights of Defour for €6 million, and he signed a five-year contract.He finished his first year with 37 appearances all competitions comprised and added two goals, helping his new team win the Primeira Liga championship.On 18 September 2012, Defour netted Porto's second goal against GNK Dinamo Zagreb, in the season's Champions League group stage (2–0 away win).