 Defour made his debut for the Belgian senior team in May 2006, aged just 18.He scored his first goal on 6 September 2008, in a 3–2 win against Estonia at his club ground the Stade Maurice Dufrasne for the 2010 FIFA World Cup qualifiers.Defour scored once in three appearances in qualification for the 2014 World Cup, opening a 2–0 win away to Scotland on 6 September 2013.