 On 13 March of the following year, for the same competition but in the round-of-16, he was booked twice and subsequently sent off in the 49th minute of the second leg of the tie at Málaga CF, as the northerners lost 0–2 at La Rosaleda Stadium and 1–2 on aggregate.On 13 August 2014, Defour signed a five-year deal with R.S.C.Anderlecht, for €6 million.