 It must be noted that the value of x is erroneously set to 0 in the quite popular C-PCM reimplementation of COSMO in Gaussian.From the thus determined solvent charges "q" and the known charge distribution of the molecule, the energy of the interaction between the solvent and the solute molecule can be calculated.The COSMO method can be used for all methods in theoretical chemistry where the charge distribution of a molecule can be determined, for example semiempirical calculations, Hartree–Fock-method calculations or density functional theory (quantum physics) calculations.