 Cayetano was born to a political family currently based in Taguig.Her father was the late former senator Rene Cayetano; her younger brother, Alan Peter, is the Speaker of the House; her youngest brother, Lino, is the mayor of Taguig; and her sister-in-law (Alan Peter's wife) Lani, is the incumbent representative of Taguig.A self-proclaimed feminist, Cayetano authored the Expanded Senior Citizens Act, Expanded Breastfeeding Promoting Act, and the Responsible Parenthood and Reproductive Health Act of 2012, among others.