 Moule's grand-nephew C. F. D. Moule was a notable theologian.Handley Moule married Harriet Mary Elliott (1844–1914) (called "Mary") on 16 August 1881; they had two children, Mary "Tesie" Moule (1882–1905) and Isabel Catherine Moule (1884–1959).In 1907 Moule published a memoir on Mary's short life entitled "The School of Suffering".