 Treatment of individuals with glutathione synthetase deficiency generally involve therapeutic treatments to address mild to severe symptoms and conditions.In order to treat metabolic acidosis, severely affected patients are given large amounts of bicarbonate and antioxidants such as vitamin E and vitamin C. In mild cases, ascorbate and "N"-acetylcysteine have been shown to increase glutathione levels and increase erythrocyte production.It is important to note that because glutathione synthetase deficiency is so rare, it is poorly understood.