 Unlike prokaryotic genomes, eukaryotic genomes were largely complex and inconsistent.It was soon accepted that 94% of human genes are interrupted, and 50% of hereditary diseases are involved in splicing intron errors out of interrupted genes.The best known example of a disease caused by a splicing error is Beta-thalassemia, in which extra intronic material is erroneously spliced into the gene for making hemoglobin.