 Following the cloning of MscL, the crystal structure of "Mycobacterium tuberculosis" MscL (Tb-MscL), was obtained in its closed conformation.In addition, the crystal structure of "Staphylococcus aureus" MscL (Sa-MscL) and Ec-MscL have been determined using X-ray crystallography and molecular model respectively.However, some evidence suggests that the Sa-MscL structure is not physiological, and is due to the detergent used in crystallization.