 He was an actor with the Rustaveli Theatre.Sakandelidze's Important roles included Gogia ("Losve Story"), Gio ("Tariel Golua"), Osiko Kharebadze ("The Autumn Nobles") Kuchara ("Kvarkvare Tutaberi"), Toshek ("Such a Love"), Chinchraka ("Chinchraka"), Butkhuza ("The Old Pipers"), Aristo Kvashavadze ("The Stepmother of Samanaishvili"), Peasant and Husband ("The Caucasian Chalk Circle"), Catesby ("Richard III"), and Scrooge in ("Christmas Dream").Karlo Sakandelidze also acted in films.