 These recent problems with artificial anti-TNF-α autoimmunity also point to the possibility of tumor necrosis factor alpha involvement in some multiple sclerosis variants.Also a previous subtype of MS associated to LHON has been described (LHON-MS) It is a presentation of LHON with MS-like CNS damage.It used to satisfy McDonalds definition for MS, but after demonstration that LHON can produce this kind of lesions, the "no better explanation" requirement does not hold anymore.