 Huixquilucan had 242,167 inhabitants at the time of the 2010 Census in Mexico.Jesuits founded a school of indigenous languages here in 1580 in the village which was then called San Antonio Huixquilucan, taking advantage of a parish left vacant by the death of its former priest.The Jesuits were then able to preach in the Otomi, Mazahua and Matlatzinca languages.