 It is not due to auto-antibodies, but to defective mitochondria instead.The symptoms of this higher form of the disease include loss of the brain's ability to control the movement of muscles, tremors, and cardiac arrhythmia.and the lack of muscular control

Apart of the previously cited spectrums (Anti-AQP4 diseases, Anti-MOG, Anti-NF and anti-TNF spectrums) there is a long list of MS variants, with possibly different pathogenesis, which are still idiopathic and considered inside the MS-spectrum.