 The N-terminal region of PKC, known as C1, has been shown

Phorbol esters (such as PMA) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues.DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC).Phorbol esters can directly stimulate PKC.