 It has also been noted that percentage of children with anti-mog antibodies respect a demyelinating sample is higher than for adults

Some NMO patients present double positive for autoantibodies to AQP4 and MOG.These patients have MS-like brain lesions, multifocal spine lesions and retinal and optic nerves atrophy.Some anti-neurofascin demyelinating diseases were previously considered a subtype of Multiple Sclerosis but now they are considered a separate entity, as it happened before to anti-MOG and anti-AQP4 cases.