 Interestingly, despite recent (and increasing) emphasis on early detection of patients with aggressive MS, the original definition of MMS was not modified by the NMSS Advisory Committee in its latest publication in 2013 (Lublin et al., 2014).Common to all definitions is the early, unexpected acquisition of disability followed by frequent relapses and highly active disease seen on MRI.One definition can be based on EDSS score and the time to develop secondary progressive MS (SPMS) (Menon et al., 2013).