 The pre-Bötzinger complex is capable of generating differential rhythmic activities due the intricate integration of modulatory, synaptic, and intrinsic properties of the neurons involved.In addition to its involvement in generating respiratory rhythm, the pre-Bötzinger complex is also capable of integrating sensory information from changes in the biochemical environment, particularly oxygen.The capability to detect focal hypoxia causes an excitatory response in the motor output responsible for respiration, which causes alterations in the firing pattern of neurons within the pre-Bötzinger complex.