 The pre-BötC is capable of generating stable respiratory rhythms with varying degrees of oxygenation and throughout varying conditions of its environment using network reconfiguration and neuromodulation.The structure contains a core network within a larger network of interconnected nuclei that function to maintain respiratory rhythms and the neuroplasticity and state-dependency of breathing.Two key features of the pre-BötC are its stability and its ability to adapt to changing environmental and behavioral conditions.