 Calcium-activated nonselective cation currents are important for the intrinsic spiking and bursting activity in CS pacemaker neurons.Metabotropic glutamate 1/5 receptors appear to be important for the increase in intracellular calcium that activate ICAN.The initial burst in a neuron usually leads to the activation of the transient sodium current and the several types of calcium currents.These currents depolarize the cell further enough to activate NMDA receptors and ICAN, which helps cell regenerate its bursts.