 The generation and modulation of eupnea and the transition between the inspiratory and expiratory phases have also been implicated in respiratory rhythm generation.The pre-BötC complex operates in animals as part of a larger network that receives critical information and signaling inputs from other areas of the brain, including the pons and parafacial nucleus.An isolated slice of the complex can continue to generate respiratory rhythmic activity and can be recorded from the hypoglossal motor nucleus, which receives input through an outside interneuronal population.