 Plessington was born in 1637 in Garstang, Lancashire, and ordained a Priest in Segovia on 25 March 1662.A year later St. Plessington returned to England where he ministered to recusant and covert Roman Catholics in Holywell and Cheshire.He was arrested during the Popish Plot scare on the charge of being a Roman Catholic priest, and then imprisoned for two months.