 Research is being conducted on the mechanisms involved, but it is currently unclear how this interneuron system is regulated.Rhythmogenesis, the generation of rhythm, is modulated by membrane properties and synaptic interactions occurring in interneurons, intrinsically-bursting pacemaker neurons, and follower neurons within the pre-Bötzinger complex.Together these neurons make up an intrinsic network that is capable of being regulated by a vast range of neurotransmitters, amino acids, and chemical signals, such as adenosine, GABA, and glycine.