 With his mentor, Dr. Frank J. Dixon, he made a series of contributions to the field of renal pathophysiology by examining the immune basis of glomerulonephritis.Unanue then joined the group headed by Dr. Brigitte Askonas at the National Institute for Medical Research at Mill Hill in London.Together, Unanue & Askonas made the seminal observation that macrophages did not completely catabolize antigens, foreshadowing development of the field of antigen processing and presentation.