 He traveled abroad from 1757 to 1760; the tour covered Lausanne (university), Northern Italy, Rome, Naples, Coire, Paris, Turin, and Holland.His maternal uncle, an Irish peer, Charles, 2nd Viscount Fane (an Opposition/Bedford Whig), was one of the two Members of Parliament (MPs) for Reading from 1754 to 1761.In 1761, De Salis stood in his namesake and uncle's place as one of the two MPs for Reading, but having been admitted to a Freeman/Burgess of the Corporation of Reading on 4 March 1761 he was well beaten at the poll on 25 March 1761.