 Psychiatry is more focused on the “internal” invisible disease, and dermatology is focused on the “external” visible disease.Connecting the two disciplines is a complex interplay between neuroendocrine and immune systems that has been described as the NICS, or the neuro-immuno-cutaneous system.The interaction between nervous system, skin, and immunity has been explained by release of mediators from NICS.1 In the course of several inflammatory skin diseases and psychiatric conditions, the NICS is destabilized.