 Laguna returned to Spain in 1536, then travelled to England, lived some years in the Netherlands and collected herbal remedies in all the places he stayed to verify Dioscorides's prescriptions.Between 1540 and 1545 he resided in Metz, becoming a doctor of the city, and from 1545 to 1554 he stayed in Italy, where he received a doctorate from the University of Bologne and was honored by the Popes Paul III and Julius III, becoming doctor to the latter pontiff.He was provided with accommodations in Venice by the Spanish ambassador Diego Hurtado de Mendoza, a preeminent humanist and proprietor of a nutritional library.