 When applied to nematodes, emodepside has been shown to have a range of effects, inhibiting muscle in the parasitic nematode "Ascaris sum" and inhibiting locomotive and pharyngeal movement in Caenorhabditis elegans in addition to having effects in other tissues such as the inhibition of egg laying.One of the ways in which this drug achieves its effects has been shown to be through binding to a group of G-protein coupled receptors called "latrophilins", first identified as being target proteins for α-latrotoxin (the other target protein of α-LTX being neurexin, a membrane receptor with laminin-like extracellular domains), a component of black widow spider venom that can cause paralysis and subsequent death in nematodes and humans alike.LAT-1 (1014 amino acids, 113 KDa coded by the B0457.1 gene) and LAT-2 (1338 amino acids, 147 KDa coded by the B0286.2 gene) are located presynaptically at the neuromuscular junction in "Caenorhabditis elegans" and share 21% amino acid identity with each other (the amino acid sequence homology LAT-1 shares with rat, bovine and human latrophilins has been shown to be 22, 23 and 21% respectively).