 His remains were interred in the church of San Miguel, in Segovia.Laguna worked on literary, historical, philosophical, political ("Europe the Self-Tormentor, that is to say, she miserably torments herself and laments her own disgrace") and medical subjects, as a typical "homo universalis" of the Renaissance.His most celebrated work is the translation into Castilian, with interesting commentaries and additions that double the original text, of Dioscorides's "Materia Medica".