 The text was reprinted in Antwerp in 1555 and was reprinted twenty-two times by the end of the eighteenth century; it was much more influential than other editions of Galen or Theophrastus in the European Renaissance, since the prescriptions of Dioscorides had a more practical nature.Laguna still considered the theory of the four humors effective, but he showed scepticism with respect to alchemy, rejecting any affirmation that did not have empirical confirmation.In spite of that, he sometimes included non-firsthand information about products from the Americas, like the antisyphilitic guaiacum, in a very confusing form.