 She married secondly John Cecil, 4th Earl of Exeter (1628–1678), a widower, on 24 January 1670.Mildmay's first son Charles, and his second son Vere, both succeeded to their father's title in turn (since Charles Fane, 3rd Earl left no descendants).Mildmay Fane's younger brother Sir Francis Fane married Elizabeth West, daughter of William West of Firbeck Hall, Yorkshire, and widow of John, Lord Darcy of the North.