 He finished this annotation in Rome (1553) and one year later, on one of his visits to Venice, he produced a printing of his edition at the same place where P. Andrea Mattioli, the principal distributor of Dioscorides in Europe (he had made a translation to Latin and another to Italian in 1544 that was reprinted seventeen times), produced his own edition.Laguna personally verified all the prescriptions of Dioscorides and added his own observations, opinions and experiences as a botanist and pharmacologist who had experimented with herbs gathered in many areas of Europe and the Mediterranean coast.His translation is clear and precise and the commentaries constitute a primary source, not just for botanical medicine of the period, but for other scientific and technical activities.