 From 1846 he was minister of Trinity Chapel, in John Street/Newnham Street, off the Edgware Road in West London, which could accommodate 1,200 people, was built and opened for Herschell by Sir Culling Eardley and other rich supporters.But his faith was to be tested many times, especially after the death of his much loved wife and his second son.In 1855 he remarried to a rich heiress, Esther Fuller-Maitland, who had been in the wings for many years and was a friend of the family.