 In 2010, he returned to Colombia, this time as the star signing for Once Caldas ahead of its participation in the 2010 Copa Libertadores, and was once again a key figure in helping his new club capture a Colombian Primera A title.In 2011, he returned to Independiente and had a fine season scoring 11 goals for the club.Castrillón signed with Major League Soccer club Colorado Rapids on January 25, 2012.