 Charlotte Harbor covers about 270 sq mi (700 km2)

Charlotte Harbor Estuary is a natural estuary spanning the west coast of Florida from Venice to Bonita Springs on the Gulf of Mexico and is one of the most productive wetlands in Florida.The estuary has a large watershed, and includes Charlotte Harbor itself as well as the Peace River, Caloosahatchee River (via Pine Island Sound) and Myakka River basins.It covers , the second largest open water estuary in the state.