 Cathelicidin rapidly destroys the lipoprotein membranes of microbes enveloped in phagosomes after fusion with lysosomes in macrophages.Cathelicidins range in size from 12 to 80 amino acid residues and have a wide range of structures.Most cathelicidins are linear peptides with 23-37 amino acid residues, and fold into amphipathic α-helices.