 Immunoreceptor tyrosine-based activation motif

An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of Non-catalytic tyrosine-phosphorylated receptors, cell-surface proteins found on immune cells.It is an integral component for the initiation of the signaling pathway and subsequently the activation of immune cells.