 NY 915E was designated as New York State Route 381 from the late 1930s to 1962 and part of NY 43 from that time to the late 1990s, when it gained its current designation.NY 915E begins just east of the Rensselaer city limits at the intersection of Third Avenue Extension and Barracks Road (NY 151) in the hamlet of Plaza View of the town of East Greenbush.NY 151 enters the intersection from the west on Third Avenue and exits to the south on Barracks Road while NY 915E heads to the northeast, paralleling a minor tributary of Mill Creek as it provides access to New Rural Cemetery and several residential housing tracts that lead away from the north side of the road.