 Brindisi took over at Club Atlético Independiente in the Primera division, he helped the club to win three titles; Clausura 1994, Supercopa Sudamericana 1994 and Recopa Sudamericana 1995.Brindisi then had a spell in charge of his former club and Independiente's fiercest rivals; Racing Club, and a period in charge of Huracán.Brindisi took over at Club Atlético Lanús in 2003, then became manager of Boca Juniors in July 2004, but resigned after only 22 games following a defeat to River Plate.