"Ladies and Gentlemen" peaked at numbers 2 and 25 on both the "Billboard" Mainstream Rock and Alternative Songs charts respectively, and is also the band's best-selling single, being certified Gold by the Recording Industry Association of America (RIAA) in 2010.An accompanying music video for the song, directed by Stephen Penta, features two women boxing each other in a ring while lead singer Josey Scott plays the role of an announcer, trainer and referee throughout the video.