 She was the fourth daughter of Charles, Duke of Durazzo (1323–1348), and Maria of Calabria, but the only one to have children; her legitimate line of descent, as well as the century-old Capetian House of Anjou, ended with her daughter.In February 1369, Margaret married her paternal first cousin Charles of Durazzo.He was a son of Louis of Durazzo, another son of John, Duke of Durazzo, and his second wife Agnes de Périgord.