 On 7 March 2018, Khedira made his 100th appearance for Juventus in a 2–1 win over Tottenham at Wembley Stadium, in the second leg of the round of 16 of the UEFA Champions League, assisting Gonzalo Higuaín's goal.In September 2018, Khedira signed a new contract with Juventus, which would keep him at the team until 2021.In February 2019 he was ruled out for a month to undergo treatment after it was diagnosed that he suffered from an irregular heartbeat.