 Snuff-taking by the Taino and Carib people of the Lesser Antilles was observed by the Franciscan friar Ramón Pané on Columbus' second voyage to the New World in 1493.Friar Pané's return to Spain with snuff signalled its arrival in Europe that would last for centuries.In the early 16th century, the Spanish Casa de Contratación (House of Trade) established and held a trade monopoly in the first manufacturing industries of snuff, in the City of Seville, which became Europe's first manufacturing and development centre for snuff.