 For haplogroup E, Hammer revised the dates from 31,000 years ago to 50,000 years ago.Hammer is also quoted as saying “The age of haplogroup DE is about 65,000 years, just a bit younger than the other major lineage to leave Africa, which is assumed to be about 70,000 years old”, in which he implies that haplogroup DE left Africa soon after haplogroup CT.

A 2018 study, based on analyzing maternal and paternal markers, their current distribution, and inferences from the DNA of the Altai Neanderthals, supports an Asian origin of paternal haplogroup DE and maternal haplogroup L3.The study suggests a back migration into Africa and a following admixture of the native Africans with immigrating peoples from Asia.