 All Y chromosomes that belong to other haplogroups and subclades are YAP-negative (YAP-).The age of haplogroup DE, previously estimated at between 65,000 and 71,000 years, was later estimated at around 73,000 years  and most recently at around 76,000 years old.The subclades of DE continue to confound investigators trying to reconstruct the migration of humans because, while they are common in Africa and East Asia, they are also largely absent between these two regions.