 Toxic granulation is often found in patients with bacterial infection and sepsis, although the finding is nonspecific.Patients being treated with chemotherapy or granulocyte colony stimulating factor, a cytokine drug, may also exhibit toxic granulation.Toxic granules are mainly composed of peroxidase and acid hydrolase enzymes, and are similar in composition to the primary granules found in immature granulocytic cells like promyelocytes.