 On 20 August 2016, Khedira opened the 2016–17 Serie A season with a goal in a 2–1 home win over Fiorentina.A week later he scored the only goal in a 1–0 away win over Lazio in the league.On 22 October 2017, Khedira scored his first career hat-trick in a 6–2 away win over Udinese.