 The subclades of DE continue to confound investigators trying to reconstruct the migration of humans because, while they are common in Africa and East Asia, they are also largely absent between these two regions.As the paragroup DE(xD,E), including DE*, is extremely rare, the majority of DE male lines fall into subclades of either D-CTS3946 or E-M96.D-CTS3946 is suggested to have originated in Africa, though its most widespread subclade, D-M174, likely originated in Asia – the only place where D-M174 is now found.