 A 2000 study concerning the origin of the YAP+ mutation analyzed 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAP+ chromosomes).They also analyzed the Out-of-Africa and out-of-Asia models for the YAP mutations.According to the authors, the most ancient YAP+ mutation was found in the Asian lineage of Tibetans, but curiously not in Japanese lineages.