 Along with Döhle bodies and toxic vacuolation, which are two other findings in the cytoplasm of granulocytes, toxic granulation is a peripheral blood film finding suggestive of an inflammatory process.Toxic granulation is often found in patients with bacterial infection and sepsis, although the finding is nonspecific.Patients being treated with chemotherapy or granulocyte colony stimulating factor, a cytokine drug, may also exhibit toxic granulation.