 Especially the ratio of CSF neurogranin trunc P75 and the beta-secretase BACE1 is suggested as potential marker for cognitive deterioration in the progress of Alzheimer’s disease.Prior to its identification in the bovine and rat brain in 1991, neurogranin was known as a putative protein kinase C-phosphorylated protein named p17.Human neurogranin was cloned in 1997 and turned out to be 96% identical to the rat protein.