 A week later he scored the only goal in a 1–0 away win over Lazio in the league.On 22 October 2017, Khedira scored his first career hat-trick in a 6–2 away win over Udinese.On 7 March 2018, Khedira made his 100th appearance for Juventus in a 2–1 win over Tottenham at Wembley Stadium, in the second leg of the round of 16 of the UEFA Champions League, assisting Gonzalo Higuaín's goal.