 Hernán Cortés led a new expedition to Mexico landing ashore at present day Veracruz on 22 April 1519, a date which marks the beginning of 300 years of Spanish hegemony over the region.In general the 'Spanish conquest of Mexico' denotes the conquest of the central region of Mesoamerica where the Aztec Empire was based.The fall of the Aztec capital of Tenochtitlan in 1521 was a decisive event, but the conquest of other regions of Mexico, such as Yucatán, extended long after Spaniards consolidated control of central Mexico.