 In the Lent of 1493, Friedrich's personal physicians diagnosed Kaiser in the left leg as a symptom, usually referred to as age-burning, in the research literature, which according to current medical terminology is considered to be the result of arteriosclerosis.On 8 June 1493 he was amputated under the direction of the surgeon Hans Seyff in the Linz castle of the affected area of the leg.This leg amputation is considered one of the most famous and best-documented surgical procedures of the entire Middle Ages.