 Malaria-resistant mosquitoes have been developed in the laboratory by inserting a gene that reduces the development of the malaria parasite and then use homing endonucleases to rapidly spread that gene throughout the male population (known as a gene drive).This approach has been taken further by using the gene drive to spread a lethal gene.In trials the populations of "Aedes aegypti" mosquitoes, the single most important carrier of dengue fever and Zika virus, were reduced by between 80% and by 90%.