 Around this time the centre of political and social importance in the Low Countries started to shift from Flanders (Bruges–Ghent) to Brabant (Antwerp–Brussels), although Ghent continued to play an important role.With Bruges, the city led two revolts against Maximilian of Austria, the first monarch of the House of Habsburg to rule Flanders.In 1500, Juana of Castile gave birth to Charles V, who became Holy Roman Emperor and King of Spain.