 The conquest was of the Chibcha-speaking nations, mainly the Muisca and Tairona indigenous people that lived here.The Spanish founded San Sebastian de Uraba in 1509—abandoned within the year, and in 1510 the first permanent Spanish mainland settlement in America, Santa María la Antigua del Darién.The first Europeans to arrive in what is modern day Mexico were the survivors of a Spanish shipwreck in 1511.