 In general the 'Spanish conquest of Mexico' denotes the conquest of the central region of Mesoamerica where the Aztec Empire was based.The fall of the Aztec capital of Tenochtitlan in 1521 was a decisive event, but the conquest of other regions of Mexico, such as Yucatán, extended long after Spaniards consolidated control of central Mexico.The Spanish conquest of Yucatán is the much longer campaign, from 1551 to 1697, against the Maya peoples of the Maya civilization in the Yucatán Peninsula of present-day Mexico and northern Central America.