 After the fall of Tenochtitlan in 1521, it took decades of sporadic warfare to subdue the rest of Mesoamerica, particularly the Maya regions of southern New Spain and into what is now Central America.But Spanish conquests in the Zapotec and Mixtec regions of southern Mesoamerica were relatively rapid.Outside the zone of settled Mesoamerican civilizations were nomadic northern "indios bárbaros" ("wild Indians") who fought fiercely against the Spaniards and their indigenous allies, such as the Tlaxcalans, in the Chichimeca War (1576–1606).