 Because the 8×68mm S offers an exceptional sturdy, pressure resistant cartridge case that can relatively easily be reloaded with primers, powder and bullets and hence be reused several times it has become quite popular amongst wildcatters.With the 8×68mm S as the parent case wildcatters have created .25×68, .270×68, 7×68mm, .30×68, .338×68, .375×68 or .416×68 variants.Improved or blown out 68 mm cartridge designs are reported to come performance wise close to the 8mm Remington Magnum which has about 14% more case capacity then the standard 8×68mm S.

Examples of 8×68mm S based wildcats are the relatively well known American 7 mm and .30 caliber Boo Boo and 7 mm and .30 HV wildcats.