 Toward the end of the Timurid power, in the middle of the 15th century, Sayram was raided regularly (along with Turkestan) by the Moghul amir Mir Haqq-Berdi Bekichek.Shaybani Khan took Sayram in 1503.With the coming of Uzbek power in the region, Sayram fell to Muhammad Shaybani Khan along with the rest of the region.