 In terms of supramolecular chemistry, chemosensing is an example of host–guest chemistry, where the presence of a guest (the analyte) at the host site (the sensor) gives rise to recognition event (e.g.sensing) that can be monitored in real time.This requires the binding of the analyte to the receptor, using all kinds of binding interactions such as hydrogen bonding, dipole- and electrostatic interactions, solvophobic effect, metal chelation, etc.