 Kalema Muguluma was the son of Kabaka Mukaabya Walugembe Muteesa I Kayiira, Kabaka of Buganda, who reigned between 1856 and 1884.His mother was Ndibuwakanyi, of the Mamba clan.He was declared Kabaka by the Muslim forces that deposed his elder brother Kabaka Kiweewa Mutebi Nnyonyintono on 21 October 1888.