 While chemosensors were first defined in the 1980s, the first example of such a fluorescent chemosensor can be documented to be that of Friedrich Goppelsroder, who in 1867, developed a method for the determination/sensing of aluminium ion, using fluorescent ligand/chelate.This and subsequent work by others, gave birth to what is considered as modern analytical chemistry.In the 1980s the development of chemosensing was achieved by Anthony W. Czarnik, A. Prasanna de Silva and Roger Tsien, who developed various types of luminescent probes for ions and molecules in solutions and within biological cells, for real-time applications.