 Acute inflammation is characterized by marked vascular changes, including vasodilation, increased permeability and increased blood flow, which are induced by the actions of various inflammatory mediators.Vasodilation occurs first at the arteriole level, progressing to the capillary level, and brings about a net increase in the amount of blood present, causing the redness and heat of inflammation.Increased permeability of the vessels results in the movement of plasma into the tissues, with resultant "stasis" due to the increase in the concentration of the cells within blood – a condition characterized by enlarged vessels packed with cells.