 Raman spectroscopy has also been used as a noninvasive technique for real-time, in situ biochemical characterization of wounds.Multivariate analysis of Raman spectra has enabled development of a quantitative measure for wound healing progress.Spatially offset Raman spectroscopy (SORS), which is less sensitive to surface layers than conventional Raman, can be used to discover counterfeit drugs without opening their packaging, and to non-invasively study biological tissue.