 The association of systemic inflammation with insulin resistance and type 2 diabetes, and with atherosclerosis is under preliminary research, although rigorous clinical trials have not been conducted to confirm such relationships.C-reactive protein (CRP) is generated at a higher level in obese people, and may increase the risk for cardiovascular diseases.The outcome in a particular circumstance will be determined by the tissue in which the injury has occurred and the injurious agent that is causing it.