 These proteins form heterodimers that enter the nucleus and bind to the "TOC1" gene promoter, repressing the production of TOC1 protein.When TOC1 protein is expressed, it serves to regulate "LHY" and "CCA1" by inhibition of their transcription.This was later supported in 2012 by Dr. Alexandra Pokhilo, who used computational analyses to show that TOC1 served this role as an inhibitor of "LHY" and "CCA1" expression.