 This gives rise to a negative feedback loop effect, which takes part in maintaining proper levels of both contrasting factors.As an example of a mechanism function of Anti-Sigma factors that it usually can play an important role instead of being a sigma factors destroyers since they inhibit some cell processes and activate another depending on some researches has been done.Researchers have studied several anti-sigma factor activities in the cell such as RsrA (Redox-sensitive), which is a key sensor of thiol–disulphide and a negative regulator ofσR (binds σR and inhibits σR-directed transcription only in vitro), what means that it needs some sensitive conditions to happen.