 Disruption of circadian rhythms may lead to loss of rhythmicity in metabolic and transcriptional processes, and even quicken the onset of certain neurodegenerative diseases such as Alzheimer's disease.In 2017, oscillators that generated circadian rhythms and were not influenced much by temperature were created in a laboratory.Pathologically, the repressilator model can be used to model cell growth and abnormalities that may arise, such as those present in cancer cells.