 Nathan Peterman, who performed the best of the three quarterbacks during the 2018 preseason, was named the opening day starter.Midway through the first regular season game, in which he failed to obtain a first down until the third quarter and threw two interceptions (the team was down 40–0 by the end of Peterman's day), he was benched in favor of Allen; that game ended up a 47–3 loss to the Baltimore Ravens.Though Allen was named starter from week 2 onward, Peterman would play several more games for the Bills after injuries to Allen but was released later in the season after several more poor performances, with Matt Barkley signed to replace him as the backup.