 Blood sampling done for laboratory testing can easily remove enough blood to produce anemia.Obladen, Sachsenweger and Stahnke (1987) studied 60 very low birth weight infants during the first 28 days of life.Infants were divided into 3 groups, group 1 (no ventilator support, 24 ml/kg blood loss), group 2(minor ventilated support, 60 ml/kg blood loss), and group 3(ventilated support for respiratory distress syndrome, 67 ml/kg blood loss).