 The census of 2005 reported a population of 49,459 in the city of Apizaco, while the municipality had 73,097 inhabitants.The city is the second largest in the state in population, behind only Villa Vicente Guerrero.The municipality has an area of 56.83 km² (21.94 sq mi) and includes a small number of other communities, the largest of which are Santa Anita Huiloac, Santa María Texcalac, and San Luis Apizaquito.