 Research has revealed bio-behavioral pathways to disease which indicates that importance of treatment of psychological concerns that emerge as a result of a cancer diagnosis in efforts to reduce the likelihood of cancer progression.Additionally, knowledge continues to advance related to treatment refractory symptoms of cancer including pain and fatigue that may be biobehaviorally driven which has advanced novel treatment approaches.Multiple evidence based treatments for mood and anxiety disorders in the general population have been adapted to deal with stressors directly related to cancer.