 A study comparing thermal ablation to sublobar resection as treatment for early stage NSCLC in older people found no difference in overall survival of the patients.It is possible that RFA followed by radiation therapy has a survival benefit due to synergism of the two mechanisms of cell destruction.The treatment approach for people who have advanced NSCLC is first aimed at relieving pain and distress (palliative), however a wide variety of chemotherapy options exist.