 Those seeking to reach the port of Veracruz by railroad from Mexico City must travel through Apizaco.The city began because of its location on this railroad.Universities in Apizaco include the Technological Institute of Apizaco ("Instituto Tecnológico de Apizaco"), and most recently, the University of the Valley of Tlaxcala ("Universidad del Valle de Tlaxcala")

The city's climate is temperate and arid.