 Topal signed for Valencia CF on 12 May 2010, for a fee believed to be in the region of €5.5 million.On 14 September, he made he first UEFA Champions League appearance with his new club, playing the full 90 minutes against Turkish side Bursaspor in a 4–0 group stage win.Topal scored his first goal with the "Che" at Sporting de Gijón, on 25 September 2010 (2–0).