 The laws of Mendelian inheritance, as summarized in the table above, show that crossing two horses with the recessive genotype (sb1/sb1 or +/+) will never produce a foal with the Sabino 1 gene, regardless of the appearance of the coat.By these same rules, the only way to guarantee a sabino-spotted foal (SB1/+) is to breed a sabino-white to a non-sabino.The mutation responsible for Sabino 1 on the KIT gene is a single nucleotide polymorphism designated KI16+1037A.