 Some of these numbers are associated with major characters in Lost while other major characters are surprisingly connected to others on the list.In his last talk to the survivors of the crash, Jacob reveals they are "just numbers".In an interview with Lostpedia, producer David Fury confirmed that the number 42 was a reference to "The Hitchhiker's Guide to the Galaxy" in which it is the answer to the question "What is the answer to the ultimate question of life, the universe, and everything?