 It is implemented in the popular homology modeling program MODELLER and used to assess the energy of the protein model generated through many iterations by MODELLER, which produces homology models by the satisfaction of spatial restraints.The models returning the minimum molpdfs can be chosen as best probable structures and can be further used for evaluating with the DOPE score.Like the current version of the MODELLER software, DOPE is implemented in Python and is run within the MODELLER environment.