 As I-10 travels through downtown, it junctions with I-45 and I-69/US 59.Both interchanges feature left exits, allowing several lane shifts for through traffic.I-10 provides access to Minute Maid Park, home of the Houston Astros, and also runs through the campus of the University of Houston–Downtown

The section east of downtown Houston is officially known as the "East Freeway", although it is widely known by locals as the Baytown East Freeway or colloquially shortened to the Beast, due to a marketing push by Baytown, one of the largest cities in the Greater Houston Area.