 The first model was introduced in 2001; the MV Agusta Brutale 750 Oro, which, like the MV Agusta F4 750 Series Oro, used many magnesium parts and was limited to 300 machines.This was followed in 2002 by the MV Agusta Brutale 750 S.

In late 2005, a larger 910 cc engine was added to the range.The 998 cc engine from the F4 1000 S was taller than the 750 cc unit and could not be fitted.