 In 1948 Weis seconded the nomination of Thomas E. Dewey for president, the first woman to do so.She went on to work as associate campaign manager for the Republican Party in the 1948 election.In 1952 Weis was a member of the caucus that helped Dwight D. Eisenhower select a running mate, an experience she described in an essay she contributed to the book, "Politics USA".