 Selection of the template for each segment is based on sequence similarity, comparisons of alpha carbon coordinates, and predicted steric conflicts arising from the van der Waals radii of the divergent atoms between target and template.The most common current homology modeling method takes its inspiration from calculations required to construct a three-dimensional structure from data generated by NMR spectroscopy.One or more target-template alignments are used to construct a set of geometrical criteria that are then converted to probability density functions for each restraint.