 Such methods usually employ implicit solvation, which provides a continuous approximation of a solvent bath for a single protein molecule without necessitating the explicit representation of individual solvent molecules.A force field specifically constructed for model assessment is known as the Effective Force Field (EFF) and is based on atomic parameters from CHARMM.A very extensive model validation report can be obtained using the Radboud Universiteit Nijmegen ""What Check"" software which is one option of the Radboud Universiteit Nijmegen ""What If"" software package; it produces a many page document with extensive analyses of nearly 200 scientific and administrative aspects of the model.