 It was used in many consumer products, e.g., nail polish, but such usages has declined since around 2006.It was banned in children's toys, in concentrations of 1000 ppm or greater, under section 108 of the Consumer Product Safety Improvement Act of 2008 (CPSIA).An example of DBP’s endocrine disruption is shown in one study, in which pregnant female rats were exposed to varying doses of DBP orally from gestational day 12.5 to 21.5.^([19]) Results showed that DBP down regulates the expression of BcI-2 (inhibit apoptosis) and up-regulates the expression of Bax (promote apoptosis) in male offspring, decreasing the BcI-2/Bax ratio.^([19]) This results in the increase of apoptosis in the seminiferous tubule cells early in male rat development.^([19]) In these male offpsrings, in-utero expression of DBP resulted in decreased anal-genital distance, decreased Sertoli cell and Leydig cell number in seminiferous tubule, and decreased sperm production.