 Vólquez made his 2010 debut with the Reds on July 17, 2010 vs the Colorado Rockies with an 8-1 win.Vólquez held the Rockies to one earned run and three hits in six innings with 9 strikeouts and 2 base on balls.However, his next several starts were unimpressive, and for the second time in his career, he was demoted straight to single-A (the Dayton Dragons).