 SR 22 is one of two primary east–west highways in Louisa County, connecting the county seat of Louisa with Charlottesville and Mineral.The state highway runs concurrently with US 33 through Louisa and with SR 208 between Louisa and Mineral.SR 22 begins at a tangent intersection with US 250 (Richmond Road) in the community of Shadwell in eastern Albemarle County.