 In 1855, Roufos was elected Mayor of Patras, a post he held for three years.When King Otto was exiled in 1862, Roufos became one of three viceroys - along with Konstantinos Kanaris and Dimitrios Voulgaris - that held power from October 10, 1862 until October 19, 1863.Roufos served twice times as Prime Minister of Greece, with his first term interrupted for a few days in June 1863.