 Other factors may tip the balance in marginal cases; for example, the template may have a function similar to that of the query sequence, or it may belong to a homologous operon.However, a template with a poor "E"-value should generally not be chosen, even if it is the only one available, since it may well have a wrong structure, leading to the production of a misguided model.A better approach is to submit the primary sequence to fold-recognition servers or, better still, consensus meta-servers which improve upon individual fold-recognition servers by identifying similarities (consensus) among independent predictions.