 It is also possible for a mutation to reduce the number of channels produced by an individual, which leads to the development of Dravet syndrome.Currently, the SCN1A gene is the most clinically relevant; the largest number of epilepsy related mutations characterized thus far occur in this gene.Typically, a missense mutation in either the S5 or S6 segment of the sodium channel pore results in a loss of channel function and the development of Dravet syndrome.