 On returning to the UK, Lane set up his own laboratory with Cancer Research Campaign (CRC) funding at Imperial College, London, then moving to the ICRF laboratories at Clare Hall before moving in 1990 to the University of Dundee to help establish the CRC laboratories there.He has played an active part in UK science, sitting at various times on the Scientific Committee of the CRC, the Cell Board of the MRC, and on the council of the ICRF.He is dedicated to the successful translation of research for patient benefit and participated in the early discussions around the scientific benefits of the merger of ICRF and CRC, before serving as Chief Scientist to their successor, Cancer Research UK, until 2010.