 In 1524 he was created Bishop of Catania, but resigned three times in favour of other members of his family.In the same year he was enfeoffed with large estates in the Duchy of Milan (County of Vespolate 1524–1530, County of Gallarate 1530).He was created a Cardinal of the Holy Roman Church by Pope Paul III on 21 May 1535, but his name was not announced publicly (it was held "in pectore" by the Pope).