 Debono was a Professor of Medicine at the University of Malta from 1946 to 1963.Professor Debono carried out original work on vaccination of goats, together with Sir Temistocles (Temi) Zammit, wrote many papers on Undulant Fever (also known as the Malta Fever) and introduced "Aureomycin", which was followed by other antibiotics, in 1949.He was the first to popularize the concept of dehydration in Infantile Diarrhorea and introduced the simple but efficient treatment which greatly reduced mortality.