 "at Ford Field, Detroit, Michigan"

Hoping to build on their win over the Falcons, the Lions stayed at home for their match-up against the San Francisco 49ers.In the first quarter, the Lions trailed as Niners RB Frank Gore got a 61-yard TD run, while kicker Joe Nedney got a 28-yard field goal.In the second quarter, Nedmey helped San Francisco get a 23-yard field goal, while Lions kicker Jason Hanson got a 25-yard field goal.