 López Mendoza was born on 29 April 1971 in Caracas, into a prominent family; his mother Antonieta Mendoza de López was vice president of corporate affairs at the media conglomerate, Cisneros Group, while his father, Leopoldo López Gil, held an executive editorial position at "El Nacional" and became a Member of the European Parliament in 2019.He has two sisters, Diana and Adriana López.López is descended from prominent Venezuelans, including a former president.