 Route 37 begins at an intersection with Hillandale Road (SR 847), a local frontage road along the east side of I-81, and Tasker Road (SR 642), which leads southeast to US 522 near Armel.It immediately crosses I-81 at exit 310, a diamond interchange with two traffic signals on SR 37, and then becomes a freeway, soon junctioning US 11 (Valley Pike) with a partial cloverleaf.The next interchange is a diamond at Cedar Creek Grade (SR 622), and SR 37 reaches its approximate midpoint at US 50 (Northwestern Pike), another diamond.