 Appointed to the chair of Philosophy at the University of Bucharest in 1906 (after three years of employment at the cultural foundation created by King Carol I), he was also the founder of the review "Studii filosofice" (later renamed "Revista de filosofie"), and, in 1918, became head of the National Theatre Bucharest.In 1923, Rădulescu-Motru joined Virgil Madgearu, Constantin Costa-Foru, Victor Eftimiu, Grigore Iunian, Radu D. Rosetti, Dem I. Dobrescu, and the socialists Constantin Titel Petrescu, Nicolae L. Lupu, and Constantin Mille, in creating "Liga Drepturilor Omului" (the League for Human Rights), protesting against measures taken by the National Liberal cabinet of Ion I. C. Brătianu in dealing with left-wing opposition forces.In 1925, Rădulescu-Motru, Nicolae Basilescu, and Traian Bratu were part of a government-appointed committee investigating the roles of A. C. Cuza and Corneliu Şumuleanu in the anti-Semitic violence having occurred at the University of Iaşi in 1923-1925.