 He was the son of Andreas Ruspini of Grumello, a minor member of a patrician family originated from Croglio, in the ancient Italian region of Como, now in the Canton Ticino (Switzerland).He was recognised as a surgeon on 18 June 1758 by the college of physical sciences in Bergamo.It seems possible that he completed his training at an earlier date and, having decided to specialise in dentistry, he then went to Paris, the accepted centre for training in this field.