 Odontogenic keratocysts originate from the odontogenic epithelium (dental lamina) in the alveolus left from tooth development stages.They are mainly thought to arise from rests of Serres.Sporadic (non-syndromic) and syndromic OKCs are associated with mutations in the gene "PTCH" found on chromosome 9q, which is part of the Hedgehog signaling pathway.