 Farther east, US 422 Bus.passes more businesses, widening to a four-lane divided highway as it crosses under Norfolk Southern's Harrisburg Line #1 before reaching a cloverleaf interchange with the US 422 freeway (West Shore Bypass).Past the US 422 interchange, the business route crosses the Schuylkill River and then the Schuylkill River Trail on the Penn Street Bridge and enters the city of Reading.