 Originally with ABS-CBN from 1995 to 1999 and again from 2003 to 2007, she became a contract artist under GMA Network in 1999–2003 and again in 2007 and currently.Dela Cruz career started with ABS-CBN in 1996 in the Primetime Drama Mara Clara and 1997–1999 Esperanza both starring Judy Ann Santos she later left the network and transferred to GMA-7 to do other Primetime Dramas such as Ikaw Lang Ang Mamahalin from 2001 to 2003 and Habang Kapiling Ka as a lead actress in late 2003 she was cast in the Primetime Drama Sana’y Wala Nang Wakas from 2003 to 2004 and then 2005 the award-winning ensemble cast of Ikaw Ang Lahat Sa Akin in 2006 she became a lead antagonist in the revival of Bituing Walang Ningning opposite Sarah Geronimo which saw her potential as an Antagonost as she did her last soap with the network in Prinsesa Ng Banyera she was given more Primetime and Afternoon dramas with GMA

Angelika Dela Cruz was born to a Filipino father Ernie Dela Cruz and an Italian-Austrian mother Angelica Egger.She has also a younger sister, Mika Dela Cruz, who is also an actress, and two brothers, Erick and Edward, one of the lead singers of the boy band "Freshmen" who died in a vehicular accident in 7 June 2010.