 SR 166 begins at an intersection with US 17 (Dominion Boulevard) just north of the Dominion Boulevard Steel Bridge over the Southern Branch Elizabeth River in the independent city of Chesapeake.The state highway heads north as Bainbridge Boulevard, a two-lane road that parallels the river through an industrial area.SR 166 passes under Interstate 64 (I-64) with no access, meets the western end of SR 190 (Great Bridge Boulevard), and crosses Newton Creek.