 US 22 headed into Reading on Penn Street and continued east to 9th Street, where it turned north and US 422 continued along Penn Street and Perkiomen Avenue east out of Reading.US 22 ran concurrent with PA 83 between 2nd and 9th streets while US 422 ran concurrent with PA 73 between Chestnut Street in Reading and 23rd Street in Mount Penn.In 1931, US 22 was moved to a more direct alignment between Harrisburg and Allentown, and US 422 was extended west along the former alignment between Harrisburg and Reading.