 With the creation of the U.S. Highway System in 1926, the road between Harrisburg and Reading was designated as part of US 22, which ran along what was designated the William Penn Highway in 1916 and PA 3 in 1924 as well as PA 13, while the road between Reading and Philadelphia was designated as US 120, which ran concurrent with PA 13.In 1928, the US 120/PA 13 designation between Reading and Philadelphia was changed to US 422/PA 17 in order to provide for one number for the Benjamin Franklin Highway.The concurrent state route designations were removed from US 22 and US 422 by 1930.