 In 2005 Rujano had his best year to date, finishing third in the Giro d'Italia and winning the mountains classification.In 2006 he left the Colombia-Selle Italia team for Quick Step and he moved to the Spanish ProTour team Caisse d'Epargne in 2008.His results were not up to the expectations of team leaders, who did not renew his contract at the end of the season.