 SR 100 continues north as Pulaski–Giles Turnpike, which crosses Walker Creek at its confluence with Little Walker Creek and intersects SR 42 (Blue Grass Trail) at Poplar Hill.The state highway expands to a four-lane divided highway again at Staffordsville, north of which the highway leaves the vicinity of Walker Creek.The two directions of SR 100 follow different alignments—northbound straight and southbound curvy—south of Pearisburg.