 The state highway enters the town of Pearisburg on Main Street, which reduces to an undivided highway and then two lanes.In the center of town, SR 100 intersects US 460 Business (Wenonah Avenue) and runs concurrently with the U.S. Highway on Main Street through downtown.At the north end of downtown, SR 100 veers northwest on Main Street, which is again four lanes, while US 460 Business heads north to its terminus at US 460.