 The son of a noble Inca family, Quispe Tito was born in Cuzco, and worked throughout his life in the district of San Sebastián; his house remains, and shows his coat of arms on its door.Quispe Tito's earliest signed painting is an "Immaculate Conception" from 1627, gilded in a fashion typical of the Cuzco school.His work is in the style of Spanish Mannerism and Flemish painting.