 Just north of the rail spur, the state highway enters the town of Dublin, where it crosses over Norfolk Southern Railway's Pulaski District rail line immediately before a partial cloverleaf interchange with US 11 (Lee Highway) adjacent to the main campus of New River Community College.SR 100 passes New River Valley Airport before crossing Little Walker Mountain.The northbound direction of the highway has a runaway truck ramp on the descent to Little Walker Creek, which the highway crosses while reducing to a two-lane road just before entering Giles County at the south end of Little Walker Creek's gorge through Walker Mountain.