 IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils.IL-17F utilizes IL-17RA and IL-17RC as its receptors, and activates the MAP kinase related pathway.IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung.