 On 10 December 2016, Falcao scored his first hat-trick in Ligue 1 in a 4–0 win against Bordeaux which boosted his 2016–17 season tally to 14 goals in 15 competitive games, and 10 goals in Ligue 1 with just 579 minutes of Ligue 1 playing time, meaning that Falcao scored an average of one Ligue 1 goal in every 58 minutes of Ligue 1 playing time.On 21 February 2017, Falcao scored two goals, the first with a diving header from Fabinho's cross from the right and the second with a chip over Willy Caballero, but missed a penalty in a 5–3 away loss to Manchester City in the Champions League's round of 16 first leg match.Despite him missing out at the second leg at home due to injury, Monaco eventually won the match 3–1 and eventually qualified to the quarter-finals with away goals rule after a 6–6 aggregate score.