 Quispe Tito is believed to have learned these styles from Italian Jesuit Bernardo Bitti, who was active at the time in Cuzco.In addition, he is believed to have known Luis de Riaño in his youth, and may have derived some elements of his style from the older artist; de Riaño, a painter from Lima, had trained in the workshop of Angelino Medoro, and so would have provided another source of Italian influence.Quispe Tito also was influenced in his work by engravings from Flanders; indeed, his best-known work, the 1681 "Signs of the Zodiac" in Cuzco Cathedral, is a series of copies of Flemish engravings in which each zodiac sign is tied to a parable from the life of Christ.