 Then, it came to the attention of the Knights of St John, the Order of Hospitallers, who set up a hospital to care for pilgrims and also to be a hostel for them on their journeys (Ysbyty Ifan means "hospital of St John").Ysbyty Ifan was on the ancient pilgrimage routes, for example, from Bangor Is Coed (Bangor-on-Dee) to Holyhead and Bardsey Island and the Cistercian Way between Aberconwy and Cymer.It is centrally located among a significant number of important pilgrimage destinations of the Middle Ages, see the map which shows only some of them.