 The next year, at the 2006 FIBA World Championship, which was held in Japan, Zisis hit a game winning 3-point shot at the end of the game against the Australian national basketball team, to give Greece a 72–69 victory.However, in the next game in the tournament, he was hit on the cheekbone and eye socket bone by the elbow of the Brazilian national basketball team's Anderson Varejão.Zisis suffered a severe facial injury that forced him to sit out for the remaining entirety of the 2006 World Championship, as the injury required surgery.