 Niccolò Acciaioli persuaded Pope Innocent VI to appoint Nerio's younger brother, John, to the important Archbishopric of Patras in Achaea in May 1360.Nerio was sent to the Peloponnese to secure his brother's installation.Next year, Niccolò and John Acciaioli decided to arrange Nerio's marriage with Florence Sanudo, Duchess of the Archipelago (or Naxos).