 A story regarding the album's creation by characters Peyton Sawyer and Ellie Harp to raise funds for breast cancer research featured as a plot element on the third season of the show.Several of the artists appearing on the album also appeared on the show, including Gavin DeGraw, Fall Out Boy, Audioslave, Tyler Hilton as well as leukemia survivor Andrew McMahon and his band, Jack's Mannequin.Bethany Joy Lenz who portrays Haley James Scott in the series also sang a song on the show that appeared on this album.