 Born to first-generation Italian American parents in New York City, Lo Bianco began his career in theater, and appeared in several Broadway productions throughout the 1960s.He transitioned to film in the 1970s, starring in the crime film "The Honeymoon Killers" (1970), William Friedkin's thriller "The French Connection" (1971), and the drama "The Seven-Ups" (1973).Lo Bianco won an Obie Award for his 1975 role in an Off-Broadway production of "Yanks-3, Detroit-0, Top of the Seventh", and subsequently earned a Tony Award nomination for Best Actor for his role as Eddie in the 1983 Broadway revival of Arthur Miller's "A View from the Bridge".