 He made his film debut in "The Sex Perils of Paulette" (1965) before appearing as a murderer in the semi-biographical crime film "The Honeymoon Killers" (1970).He subsequently appeared as Salvatore Boca in William Friedkin's critically acclaimed action film "The French Connection" (1971), and later starred as a police officer investigating a series of murders in Larry Cohen's horror film "God Told Me To" (1976).From 1974–1976, Lo Bianco was a regular in Joseph Wambaugh's television series "Police Story" in the mid-1970s, opposite actors Don Meredith and Chuck Connors.