 During the era of Spanish missions in California, the Tamyen's lives changed with the Mission Santa Clara, and later the Mission San José of Fremont (founded in 1797) built in their region.Most moved into one of these missions and were baptized, lived and educated to be Catholic "neophytes", also known as Mission Indians, until the mission was discontinued by the Mexican Government in 1834.A large majority of the Tamyen died from disease in the missions.