 These programs will, as "TSR" implies, stay resident in memory while other programs are executing.Some of them do not have an option for unloading themselves from memory, so calling TSR means the program will remain in memory until a reboot.However unloading is possible externally, using utilities like the MARK.EXE/RELEASE.EXE combo by TurboPower Software or "soft reboot" TSRs which will catch a specific key combination and release all TSRs loaded after them.