 His best friend, college professor Yale Pollack (Michael Murphy), married to Emily (Anne Byrne), is having an affair with Mary Wilkie (Diane Keaton).Mary's ex-husband and former teacher, Jeremiah (Wallace Shawn), also appears, and Isaac's ex-wife Jill Davis (Meryl Streep) is writing a confessional book about their marriage.Jill has also since come out as a lesbian and lives with her partner, Connie (Karen Ludwig).