 Untreated, uveitis can lead to permanent vision loss.Inflammation may also involve the white part of the eye (sclera) or the overlying connective tissue (episclera), causing conditions called scleritis and episcleritis, respectively.UC may cause several joint manifestations, including a type of rheumatologic disease known as Seronegative arthritis, which may affect few large-joints (oligoarthritis), the vertebra (ankylosing spondylitis) or several small joints of the hands and feet (peripheral arthritis).