 Medical management may involve treating infectious causes and stopping medication that could be contributing to the jaundice.The itchiness may be helped by draining the gallbladder or ursodeoxycholic acid.Hyperbilirubinemia, more precisely hyperbilirubinemia due to the unconjugated fraction, may cause bilirubin to accumulate in the gray matter of the central nervous system, potentially causing irreversible neurological damage leading to a condition known as kernicterus.