 However, nicotine therapy is generally not recommended due to side effects and inconsistent results.The gradual loss of blood from the gastrointestinal tract, as well as chronic inflammation, often leads to anemia, and professional guidelines suggest routinely monitoring for anemia with blood tests repeated every three months in active disease and annually in quiescent disease.Adequate disease control usually improves anemia of chronic disease, but iron deficiency anemia should be treated with iron supplements.