 This process of disulfide rearrangement (known as "disulfide shuffling") does not change the number of disulfide bonds within a protein, merely their location (i.e., which cysteines are bonded).Disulfide reshuffling is generally much faster than oxidation/reduction reactions, which change the number of disulfide bonds within a protein.The oxidation and reduction of protein disulfide bonds "in vitro" also generally occurs via thiol–disulfide exchange reactions.