 Over 95% of people with coeliac have the isoform of DQ2 or DQ8, which is inherited in families.The reason these genes produce an increase in risk of coeliac disease is that the receptors formed by these genes bind to gliadin peptides more tightly than other forms of the antigen-presenting receptor.Therefore, these forms of the receptor are more likely to activate T lymphocytes and initiate the autoimmune process.