 Other studies have linked specific strains of enteroadherent "E. coli" to the disease.Adherent-invasive Escherichia coli (AIEC), are more common in people with CD, have the ability to make strong biofilms compared to non-AIEC strains correlating with high adhesion and invasion indices of neutrophils and the ability to block autophagy at the autolysosomal step, which allows for intracellular survival of the bacteria and induction of inflammation.Inflammation drives the proliferation of AIEC and dysbiosis in the ileum, irrespective of genotype.