 Many of the loci detected have been found in association with other autoimmune diseases.One locus, the LPP or lipoma-preferred partner gene, is involved in the adhesion of extracellular matrix to the cell surface, and a minor variant (SNP = rs1464510) increases the risk of disease by approximately 30%.This gene strongly associates with coeliac disease (p < 10−39) in samples taken from a broad area of Europe and the US.