 Mechanisms of these drugs causing pancreatitis are not known exactly; but it is possible that statins have direct toxic effect on the pancreas or through the long-term accumulation of toxic metabolites.Meanwhile, ACE inhibitors cause angioedema of the pancreas through the accumulation of bradykinin.Birth control pills and HRT cause arterial thrombosis of the pancreas through the accumulation of fat (hypertriglyceridemia).