 LY354740 has also been demonstrated to act on the metabotropic glutamate receptor 3 (GRM3) of human adrenocortical cells, downregulating aldosterone synthase, CYP11B1, and the production of adrenal steroids (i.e.aldosterone and cortisol).Glutamate does not easily pass the blood brain barrier, but, instead, is transported by a high-affinity transport system.