 Fexofenadine, an antihistamine drug used in treatment of allergies, has shown promise in a combination therapy in some studies.Opportunely, low gastrointestinal absorption (or high absorbed drug gastrointestinal secretion) of fexofenadine results in higher concentration at the site of inflammation.Thus, the drug may locally decrease histamine secretion by involved gastrointestinal mast cells and alleviate the inflammation.