 Homocitrate is enzymatically dehydrated by homoaconitase (HAc) (E.C 4.2.1.36) to yield "cis"-homoaconitate.HAc then catalyses a second reaction in which "cis"-homoaconitate undergoes rehydration to produce homoisocitrate.The resulting product undergoes an oxidative decarboxylation by homoisocitrate dehydrogenase (HIDH) (E.C 1.1.1.87) to yield α‑ketoadipate.