 Some studies suggest there is a role for chemoprotection in the prevention of colorectal cancer in Crohn's involving the colon; two agents have been suggested, folate and mesalamine preparations.Also, immunomodulators and biologic agents used to treat this disease may promote developing extra-intestinal cancers.Individuals with Crohn's disease are at risk of malnutrition for many reasons, including decreased food intake and malabsorption.