 Henry is out of prison, and after AJ overdoses on Draxx, the insect-killing gel that Bug-Be-Gone uses, the police try to solve a break-in at the extermination company.Sal, the head scientist at Bug-Be-Gone, discovers that insects mutate after prolonged exposure to Draxx, skipping their evolution up several generations.After Henry and his new partner clean out a run-down apartment complex and a swarm of mutant cockroaches attack them, Henry breaks up with his girlfriend who is working at the company that produces Draxx and plans to market it as a street drug to wipe out poorer neighborhoods.