 NK cells recognize the HLA-E+peptide complex using the heterodimeric receptor CD94/NKG2A/B/C.When CD94/NKG2A or CD94/NKG2B is engaged, it produces an inhibitory effect on the cytotoxic activity of the NK cell to prevent cell lysis.However, binding of HLA-E to CD94/NKG2C (see KLRC2) results in NK cell activation.