 PA 340 crosses the West Branch Brandywine Creek and runs along the border between West Brandywine Township to the north and Coatesville to the south as it comes to the junction with PA 82 in the community of Siousca.Following this intersection, the road becomes East Kings Highway and runs along the border between West Brandywine Township to the north and Valley Township to the south as it runs through forested areas with some homes.The route enters Caln Township and heads southeast, passing over the US 30 freeway.