 The road runs through areas of homes and businesses, passing south of the Harrisburg Area Community College Lancaster Campus before briefly forming the border between the city of Lancaster to the north and East Lampeter Township to the south.Farther east, the route heads between industrial parks to the north and neighborhoods to the south before coming to an interchange with the US 30 freeway that does not have a ramp from westbound US 30 to PA 340.Past this interchange, PA 340 runs through less dense areas of residential and commercial development with some farm fields.