 PA 722 crosses the Little Conestoga Creek into Manheim Township and becomes Petersburg Road, winding east through suburban residential areas with some businesses and crossing Fruitville Pike.The route heads through Groffs Corner and passes to the south of a farm before turning southeast past more homes and reaching a junction with PA 501 in Neffsville.At this point, PA 722 turns north to form a concurrency with PA 501 on Lititz Pike, passing through suburban development.