 On 6 February 2008, Cavani made his first senior appearance for the Uruguayan senior team, scoring in a 2–2 draw with Colombia.He scored from his own area on the counterattack from a corner.On 22 June 2010, in the final match of the group stage of the 2010 World Cup, Cavani set-up a goal for Luis Suárez in a 1–0 win over Mexico.