 Other mutations causing spontaneous HR are present in proteins involved in ROS production during pathogen invasion.HR is also a temperature-sensitive process and it has been observed that in many cases plant-pathogen interactions do not induce HR at temperatures above 30° C, which subsequently leads to increased susceptibility to the pathogen.The mechanisms behind the influence of temperature on plant resistance to pathogens are not understood in detail, however, research suggests that the NLR protein levels might be important in this regulation.