 He made his major league debut on April 17, 2007, against the Cleveland Indians.He pitched 5 innings for his first major league win.In his second start on April 22, Wright faced the Boston Red Sox at Fenway Park, where he became the second pitcher in major league history to give up four consecutive home runs; he surrendered home runs during the third inning to Red Sox players Manny Ramírez, J. D. Drew, Mike Lowell, and Jason Varitek.