 Around 20 % of all CC-NLRs have the MADA motif, implying the motif’s importance for the execution of HR.Accidental activation of HR through the NLR proteins could cause vast destruction of the plant tissue, thus, the NLRs are kept in an inactive form through tight negative regulation at both transcriptional and post-translational levels.Under normal conditions, the mRNA of NLRs are transcribed at very low levels, which results in low levels of protein in the cell.