 Additionally, on April 10, 1984, notorious serial killer Richard Ramirez committed his first known murder in a hotel basement, where he was living, in the Tenderloin district.High prevalence of sex work in the Tenderloin area has been associated with a high rate of sexually transmitted infections, including HIV, especially among men who have sex with other men and those who also inject drugs.Contributing factors include a lack of sex education and safe sex practices, including condom use.