 A blue coloration of the sclera may be noticed in some cases of iron-deficiency anemia.There may be signs of specific causes of anemia, e.g., koilonychia (in iron deficiency), jaundice (when anemia results from abnormal break down of red blood cells – in hemolytic anemia), bone deformities (found in thalassemia major) or leg ulcers (seen in sickle-cell disease).In severe anemia, there may be signs of a hyperdynamic circulation