 Glaucoma, particularly primary open-angle glaucoma, is associated with mutations in several genes, including "MYOC, ASB10, WDR36, NTF4", "TBK1", and "RPGRIP1", although most cases of glaucoma do not involve these genetic mutations.Normal-tension glaucoma, which comprises one-third of POAG, is also associated with genetic mutations (including "OPA1" and "OPTN" genes).Various rare congenital/genetic eye malformations are associated with glaucoma.