 Limitations of MCV include cases where the underlying cause is due to a combination of factors – such as iron deficiency (a cause of microcytosis) and vitamin B12 deficiency (a cause of macrocytosis) where the net result can be normocytic cells.The "kinetic" approach to anemia yields arguably the most clinically relevant classification of anemia.This classification depends on evaluation of several hematological parameters, particularly the blood reticulocyte (precursor of mature RBCs) count.