 She voiced of Tzipporah for animated film "The Prince of Egypt" (1998).She served as an executive producer and starred as the divorced single mother architect Melanie Parker in the romantic comedy "One Fine Day" (1996) with George Clooney, Subsequent performances included Rose Cook Lewis in the film adaptation of Jane Smiley's Pulitzer Prize-winning novel "A Thousand Acres" (1997) with Jessica Lange and Jennifer Jason Leigh; Beth Cappadora in "The Deep End of the Ocean" (1998) about a married couple who found their son who was kidnapped nine years ago; Titania the Queen of the Fairies in "A Midsummer Night's Dream" (1999) with Kevin Kline, Rupert Everett and Stanley Tucci; and Katie Jordan in Rob Reiner's comedy-drama "The Story of Us" (1999) with Bruce Willis.Pfeiffer chose to begin the process of dissolving her film production company, Via Rosa Productions, in 1999, and move into semi-retirement in order to spend more quality time with her children and family, meaning that she would continue to star in films sporadically into the 2000s and beyond.