 10-hydroxy-bis-α-dihomo-HxA5) was formed (or inferred to be formed based on the formation of their tihydroxy metabolites (see trioxilins, below) as a result of adding docosahexaenoic acid to the pineal gland or hippocampus isolated from rats; the pathway(s) making these products has not been described.A hepoxilin-like metabolite of linoleic acid forms in the skin of humans and rodents.This hepoxilin is esterified to sphinganine in a lipid complex termed EOS (i.e.