 esterified omega-hydroxyacyl-sphingosine, see Lipoxygenase#Biological function and classification#Human lipoxygenases) that also contains a very long chain fatty acid.In this pathway, ALOX12B metabolizes the esterified linoleic acid to its 9"R"-hydroperoxy derivative and then ALOXE3 metabolizes this intermediate to its 13"R"-hydroxy-9"R",10"R"-epoxy product.The pathway functions to deliver very long chain fatty acids to the cornified lipid envelope of the skin surface.