 ALOX15 is responsible for metabolizing arachidonic acid to 14,15-HxA3 and 14,15-HxB3 as indicated in the following two-step reaction which first forms 15("S")-hydroperoxy-5"Z",8"Z",11"Z",13"E"-eicosatetraenoic acid (15"S"-HpETE) and then two specific isomers of 11"S/R"-hydroxy-14"S",15"S"-epoxy-5"Z",8"Z",12"E"-eicosatrienoic acid (i.e.14,15-HxA3) and 13"S/"R)-hydroxy-14"S",15"S"-epoxy-5"Z",8"Z",11"Z"-eicosatrienoic acid (i.e.14,15-HxB3)