 On March 15, 2012, Gregory signed with the New England Patriots.On Thanksgiving Night—November 22, 2012—Gregory had a primary role in the Patriots' victory over his home-town team, the New York Jets.In the game, Gregory had an interception, 2 recovered fumbles (one leading to a touchdown, during the now infamous butt fumble play), 5 tackles, and 1 pass deflection.