 HxA3 and HxB3, in particular, are being rapidly metabolized to TrXA3, TrXB3, and TrXC3.Hepoxilins have various biological activities in animal models and/or cultured mammalian (including human) tissues and cells.The TrX metabolites of HxA3 and HxB3 have less or no activity in most of the systems studied but in some systems retain the activity of their precursor hepoxilins.