 Businesses (operating) 
Rural Municipality of Argyle No.1 
Gainsborough Swimming pool - open July and August
Movie Theater - open during the spring and fall
Riverside Hotel - beverage room, steak pit and coffee shop
Gainsborough Coop - hardware, fuel, lumber
Gainsborough and Area Health Centre - primarily for long-term care.Credit Union - branch office of the Prairie Pride Credit Union
Gainsborough Library - branch of the Southeast Regional Library 
Gainsborough Fine Foods (grocery) 
Gainsborough Frozen Foods 
A + H Farm Supplies and Insurance - SGI agent and Bus Depot
CA Shaw Insurance Broker
Gainsborough Community Rink - curling (4 sheets, artificial), skating (natural ice), beverage room
Gainsborough Volunteer Fire Department
Happy Hours Club - Local Senior's establishment
Evergreen Lodge - Seniors apartments
Canada Post
Rebel Oilfield Maintenance
Cowan Oilfield Services
Several independent business provide construction and oilfield contracting

Businesses (closed)
Grain elevators