 Tempesta and the Flemish painter Matthijs Bril were commissioned by Pope Gregory XIII to paint wide panoramas of the "Procession to Transfer the Relics of St. Gregory of Nazianzus" (1572) for the loggias on the third floor of the Vatican Palace.He completed frescoes in the Palazzina Gambara at the Villa Lante in (1578-1609).From 1579–83, Tempesta participated in the decoration of the Villa Farnese in Caprarola, notably of this villa's Scala Regia.