 On September 20, 2010, Moore was removed as the Panthers starting quarterback in favor of rookie Jimmy Clausen, after throwing 4 interceptions in the first two games.After sitting out for 3 straight games, Moore was again declared the Panthers starting quarterback on October 18, 2010, following poor play by Clausen.In his first game back as a starter against the San Francisco 49ers, Moore completed 28 passes on 41 attempts for 308 yards, two touchdowns and one interception, setting career highs in yards and completions.