 The highway was built from Urbana to MD 75 in the mid-1930s and from Buckeystown to Urbana in the late 1930s.MD 80 was relocated at its western end in the mid-1970s and relocated and expanded through Urbana in the 2000s.MD 80 begins at an intersection with MD 85 (Buckeystown Pike) south of the Buckeystown Historic District.