 SR 59 begins at an intersection with SR 47 (Main Street) in the northern part of the town of Drakes Branch opposite Saxkey Road.The state highway heads northeast from SR 47 as Gethsemane Church Avenue, then becomes unnamed after leaving the town limits.SR 59 follows the height of land between Twittys Creek to the south and Ash Camp Creek to the north; both streams empty into Roanoke Creek west of Drakes Branch.