 In 1922 many Gallipoli Serbs, adherents of the Patriarchate of Constantinople, arrived in Yugoslavia as refugees from Gelibolu and part of them were resettled here.Their number in Pehčevo was ca 1,100

From 1929 to 1941, Pehčevo was part of the Vardar Banovina of the Kingdom of Yugoslavia.From 1941 to 1944, during the Axis occupation of Yugoslavia, Pehčevo, along with most of Vardar Macedonia, was annexed by the Kingdom of Bulgaria.