 This results in channels working cooperatively when they open at the same time to allow more calcium ions to enter and then close together to allow the cell to relax.Mutation in the CACNA1C gene, the single-nucleotide polymorphism located in the third intron of the Cav1.2 gene, are associated with a variant of Long QT syndrome called Timothy's syndrome and also with Brugada syndrome.Large-scale genetic analyses have shown the possibility that CACNA1C is associated with bipolar disorder  and subsequently also with schizophrenia.