 Besides his sermon preached before Innocent VIII, Mantuan's most notable works in prose include "De patientia", a rambling discourse on physical and spiritual illness that includes an early allusion to Columbus' discovery of America, and "De vita beata", a dialogue on the religious life that he wrote soon after entering the Carmelite order.He is also known for his "Opus aureum in Thomistas", an early humanist critique of the late medieval philosophy and theology associated with Thomas Aquinas.Mantuan wrote over 55,000 lines of verse, and it is largely through his poetry that he became famous and influential on the cultures of early modern Europe.