 Signer's first major league win came as a relief pitcher in an 8–7 victory over the Philadelphia Blue Jays at Wrigley Field (September 23, 1943).His best game as a big leaguer was on October 1, 1943 when he pitched a complete game 3–1 win at home vs. the Boston Braves.Two years later, in 1945, Signer pitched six games in relief for the Cubs with no starts.