 Presence of these clones may be associated with tissue injury but in any case suggests specific therapy be directed at reducing the size and suppressing the growth of the eosinophil clone.More recently, mutations in other genes have been described as causing a similar type of clonal hypereosinophilia but have not yet been recognized as entities distinct from idiopathic hypereosinophilia and the idiopathic hyperesoniphilic syndrome.These include gene mutations in "JAK2", "ABL1", and "FLT2" and chromosomal translocations that create the "ETV6-ACSL6" fusion gene.