 Unlike its preceding singles "Jerry Was a Race Car Driver" and "Tommy the Cat", "Tweekers" did not feature an accompanying video.The song opens with Larry LaLonde on guitar and a reserved bassline from Les Claypool, from there alternating between his trademark slap bass and a quiet section for the vocals.The song's narrative describes several different trades that the town's blue collar tweekers engage in, but, like many of the other story-telling songs in Primus's catalogue, lacks any clear, single meaning and leaves plenty of ambiguity in its lyrics.