 Defensive coordinator Ron Meeks retained Bethea and Bob Sanders as the starting safeties to begin the regular season.On September 30, 2007, Bethea collected seven solo tackles during a 38–20 victory against the Denver Broncos in Week 4.The following week, he collected a season-high seven combined tackles, a pass deflection, and an interception in the Colts' 33–14 victory against the Tampa Bay Buccaneers in Week 5.