 Treprostinil can be administered subcutaneously as supplied.It must be diluted for intravenous infusion with either sterile water or a 0.9% sodium chloride solution prior to administration.The infusion rate is normally initiated at 1.25 ng/kg/min for new patients, but may be reduced to 0.625 ng/kg/min if the normal rate provokes unwanted side effects in the patient.