 The highway parallels a rail line through its intersection with SR 337 (Portsmouth Boulevard), then veers away from the railroad to meet I-264 at a partial cloverleaf interchange with a flyover ramp from southbound US 17 to the eastbound Interstate.US 17 has another at-grade railroad crossing before the highway intersects SR 337 Alternate (Turnpike Road).Just north of its oblique intersection with US 58, US 17 turns west onto High Street.