 On November 28, 2010, Bethea made six combined tackles and was credited with half a sack on Philip Rivers in the Colts' 36–14 loss to the San Diego Chargers in Week 12.The following week, he recorded a season-high 15 combined tackles (11 solo) during a 38–35 loss to the Dallas Cowboys in Week 13.He finished with 107 combined tackles (77 solo), five pass deflections, an interception, a forced fumble, and half a sack in 16 games and 16 starts.