 For primary immunodeficiencies that are caused by genetic mutation does not exist a causal therapy that would "repair" the mutation.Although there is a therapeutic option, gene therapy which has been in a trial for few immune deficiencies affecting the hematopoietic system.Over the past two decades there were some successful treatments of patients with specific primary immunodeficiencies (PID), including X-linked severe combined immunodeficiency (SCID), Wiskott–Aldrich syndrome and metabolic conditions such as leukodystrophy.