 In Week 3, he collected a season-high 12 combined tackles (eight solo) and broke up a pass in the Colts' 21–14 win against the Jacksonville Jaguars.On November 5, 2006, Bethea recorded nine combined tackles, two pass deflections, and intercepted a pass by Tom Brady during a 27–20 victory at the New England Patriots in Week 9.He was inactive during the Colts' Week 13 loss at the Tennessee Titans due to an injury.