 It may also be associated with lop ears, ectropion and hypertelorism.There are two known types, type 1 and type 2.Although research is limited, it is known that type 1 and 2 are expressed with the same symptoms mentioned above, but type 1 also has the characteristic of premature ovarian insufficiency (POI) in women, which causes menopausal symptoms in patients as young as 15 years old.