 He became a member of the CIA after that organization was established in September 1947 and eventually CIA Station Chief in Athens.Karamessines came to work in the Office of Policy Coordination (OPC), the covert operations wing of the CIA created in 1948, directed by Frank Wisner.The OPC concentrated on "propaganda, economic warfare; preventive direct action, including sabotage, anti-sabotage, demolition and evacuation measures; subversion against hostile states, including assistance to underground resistance groups, and support of indigenous anti-Communist elements in threatened countries of the free world."