 SR 251 begins at an intersection with Turnpike Road, which heads east as SR 672 and west as SR 770, at Collierstown in a valley southwest of House Mountain and east of North Mountain in western Rockbridge County.The state highway heads southeast as Collierstown Road along Colliers Creek, which empties into Buffalo Creek.After following the latter creek, SR 251 has a curvaceous ascent out of the stream valley.