 Izquierdo's canvases have a provincial simplicity, inspired by folk devotional art and French painters such as Henri Matisse and Manet.In particular, they exhibit a "masterly use of colour" and frequently include cupboards, altars, fruit, horses, portraits, and the circus.In 1945 Izquierdo became the first woman to be granted a major governmental mural commission, in the central stairwell of the Department of the Federal District government building.