 His group has published extensively on this topic, and has completed the synthesis of more than 140 natural target compounds, with notable examples including indanamycin, routiennocin, avermectin B1a, okadaic acid, spongistatin, thapsigargin, epothilone A, antascomicin B, bengazole A and rapamycin.His total synthesis of azadirachtin, completed in 2007, is widely regarded as one of the major landmarks in total synthesis.In the course of this work, he has also made substantial advances in many areas of organic chemistry, including the development of new catalysts, protecting groups and reagents.