 An uncertainty analysis is carried out so as to analyze the effects of different assumptions.When estimating the environmental burden of disease, a number of potential sources of error may arise in the measure of exposure and exposure-risk relationship, assumptions made in applying the exposure or exposure-risk relationship to the relevant country, health statistics, and, if used, expert opinions.Generally, it is not possible to estimate a formal confidence interval, but it is possible to estimate a range of possible values the environmental disease burden may take based on different input parameters and assumptions.