 Upon reaching the eastern bank of the Susquehanna River, PA 462 heads into the borough of Columbia and passes over Norfolk Southern's Port Road Branch and PA 441 before descending off the Veterans Memorial Bridge and heading northeast into industrial areas on Chestnut Street.The route crosses North 3rd Street, which provides access to US 30 and PA 441, and heads into residential areas, turning southeast onto North 5th Street.PA 462 continues southeast onto Lancaster Avenue and passes more homes.